Papers In Press, published online ahead of print July 3, 2001
J. Biol. Chem, 10.1074/jbc.M104978200
Submitted on May 31, 2001
Revised on July 3, 2001
Accepted on July 3, 2001
Functional importance of Stat3 tetramerization in activation of the alpha2-macroglobulin gene
Xiaokui Zhang and James E. Darnell
Laboratory of Molecular Cell Biology, The Rockefeller University, New York, NY 10021
Corresponding Author: darnell{at}mail.rockefeller.edu
A tetrameric Stat3 complex was found to be essential in transfection experiments for maximal IL-6-inducible activation of a2-macroglobulin gene promoter. Stable tetramer formation of purified phosphorylated Stat3 was dependent on protein-protein interaction involving the N-terminal domain of Stat3. The functional importance of tetramer formation was shown by the decreased levels of transcriptional activation associated with hypomorphic mutations in N-terminal residues.
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