JBC Origene Your Gene Company

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on November 2, 2001
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
276/45/42477    most recent
M106660200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Amor, J. C.
Right arrow Articles by Kahn, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Amor, J. C.
Right arrow Articles by Kahn, R. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print September 4, 2001
J. Biol. Chem, 10.1074/jbc.M106660200
Submitted on July 16, 2001
Revised on September 4, 2001
Accepted on September 4, 2001

Structures of yeast ARF2 and ARL1: distinct roles for the N-terminus in the structure and function of ARF family GTPases

Juan C. Amor, John Horton, Xinjun Zhu, Yi Wong, Cameron Sullards, Dagmar Ringe, Xiaodong Cheng, and Richard A. Kahn

Department of Biochemistry, Emory University, Atlanta, GA 30322-3050

Corresponding Author: rkahn{at}emory.edu

Structures were determined by x-ray crystallography for two members of the ARF family of regulatory GTPases, yeast ARF1 and ARL1, and were compared to previously determined structures of human ARF1 and ARF6. These analyses revealed an overall conserved fold but differences in primary sequence and length, particularly in an N-terminal loop, lead to differences in nucleotide and divalent metal binding. Packing of hydrophobic residues is central to the interplay between the N-terminal "-helix, switch I, and the inter-switch region, which along with differences in surface electrostatics provide explanations for the different biophysical and biochemical properties of ARF and ARL proteins.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Splingard, J. Menetrey, M. Perderiset, J. Cicolari, K. Regazzoni, F. Hamoudi, L. Cabanie, A. El Marjou, A. Wells, A. Houdusse, et al.
Biochemical and Structural Characterization of the Gem GTPase
J. Biol. Chem., January 19, 2007; 282(3): 1905 - 1915.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. D. Seidel III, J. C. Amor, R. A. Kahn, and J. H. Prestegard
Conformational Changes in Human Arf1 on Nucleotide Exchange and Deletion of Membrane-binding Elements
J. Biol. Chem., November 12, 2004; 279(46): 48307 - 48318.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Hill, Y. Li, M. Bennett, M. McKay, X. Zhu, J. Shern, E. Torre, J. J. Lah, A. I. Levey, and R. A. Kahn
Munc18 Interacting Proteins: ADP-RIBOSYLATION FACTOR-DEPENDENT COAT PROTEINS THAT REGULATE THE TRAFFIC OF {beta}-ALZHEIMER'S PRECURSOR PROTEIN
J. Biol. Chem., September 19, 2003; 278(38): 36032 - 36040.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
C. Grayson, F. Bartolini, J. P. Chapple, K. R. Willison, A. Bhamidipati, S. A. Lewis, P. J. Luthert, A. J. Hardcastle, N. J. Cowan, and M. E. Cheetham
Localization in the human retina of the X-linked retinitis pigmentosa protein RP2, its homologue cofactor C and the RP2 interacting protein Arl3
Hum. Mol. Genet., November 15, 2002; 11(24): 3065 - 3074.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Jochum, D. Jackson, H. Schwarz, R. Pipkorn, and B. Singer-Kruger
Yeast Ysl2p, Homologous to Sec7 Domain Guanine Nucleotide Exchange Factors, Functions in Endocytosis and Maintenance of Vacuole Integrity and Interacts with the Arf-Like Small GTPase Arl1p
Mol. Cell. Biol., July 1, 2002; 22(13): 4914 - 4928.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
E. S. Click, T. Stearns, and D. Botstein
Systematic Structure-Function Analysis of the Small GTPase Arf1 in Yeast
Mol. Biol. Cell, May 1, 2002; 13(5): 1652 - 1664.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Bartolini, A. Bhamidipati, S. Thomas, U. Schwahn, S. A. Lewis, and N. J. Cowan
Functional Overlap between Retinitis Pigmentosa 2 Protein and the Tubulin-specific Chaperone Cofactor C
J. Biol. Chem., April 19, 2002; 277(17): 14629 - 14634.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. D. Sharer, J. F. Shern, H. Van Valkenburgh, D. C. Wallace, and R. A. Kahn
ARL2 and BART Enter Mitochondria and Bind the Adenine Nucleotide Transporter
Mol. Biol. Cell, January 1, 2002; 13(1): 71 - 83.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.