JBC Origene Your Gene Company

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on November 30, 2001
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
276/49/45564    most recent
M108757200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kelly, A.
Right arrow Articles by Lynch, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kelly, A.
Right arrow Articles by Lynch, M. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print October 1, 2001
J. Biol. Chem, 10.1074/jbc.M108757200
Submitted on September 11, 2001
Revised on October 1, 2001
Accepted on September 28, 2001

The anti-inflammatory cytokine, IL-10, blocks the inhibitory effect of IL-1beta on LTP: A role for JNK

Áine Kelly, Aileen Lynch, Emily Vereker, Yvonne Nolan, Patrice Queenan, Elizabeth Whittaker, Luke A. J. O' Neill, and Marina A. Lynch

Department of Physiology, Trinity College Institute of Neuroscience, Dublin D2

Corresponding Author: lynchma{at}tcd.ie

Several effects of the proinflammatory cytokine, interleukin-1beta (IL-1beta ), have been described in the central nervous system and one area of the brain in which marked changes have been reported is the hippocampus. Among these changes are an IL-1beta -induced inhibition of long-term potentiation (LTP) in perforant path-granule cell synapses and an attenuation of glutamate release in synaptosomes prepared from hippocampus. Evidence suggests that, at least in circulating cells, the anti-inflammatory cytokine, IL-10, antagonizes certain effects of IL-1. Here, we investigated the effect of IL-10 on IL-1beta -induced inhibition of LTP and glutamate release. The evidence presented indicates that IL-1beta stimulates the stress-activated protein kinase, c-Jun-activated protein kinase (JNK) and IL-1 receptor associated kinase which may explain its inhibitory effect on release and LTP, and that IL-10 reversed the IL-1beta -induced stimulation of JNK activity and inhibition of release and LTP. We observed that IL-10 abrogated the stimulatory effect of IL-1beta on superoxide dismutase activity and reactive oxygen species production, while the H2O{sub2)-induced inhibition of LTP was also blocked by IL-10. We present evidence which suggests that the action of IL-10 may be mediated by its ability to induce shedding of the IL-1 Type I receptor.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
D. Srinivasan, J.-H. Yen, D. J. Joseph, and W. Friedman
Cell Type-Specific Interleukin-1{beta} Signaling in the CNS
J. Neurosci., July 21, 2004; 24(29): 6482 - 6488.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. A. LYNCH
Long-Term Potentiation and Memory
Physiol Rev, January 1, 2004; 84(1): 87 - 136.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Lynch, M. Moore, S. Craig, P. E. Lonergan, D. S. Martin, and M. A. Lynch
Analysis of Interleukin-1{beta}-induced Cell Signaling Activation in Rat Hippocampus following Exposure to Gamma Irradiation: PROTECTIVE EFFECT OF EICOSAPENTAENOIC ACID
J. Biol. Chem., December 19, 2003; 278(51): 51075 - 51084.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Minogue, A. W. Schmid, M. P. Fogarty, A. C. Moore, V. A. Campbell, C. E. Herron, and M. A. Lynch
Activation of the c-Jun N-terminal Kinase Signaling Cascade Mediates the Effect of Amyloid-{beta} on Long Term Potentiation and Cell Death in Hippocampus: A ROLE FOR INTERLEUKIN-1{beta}?
J. Biol. Chem., July 18, 2003; 278(30): 27971 - 27980.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.