JBC Focus on PI3-Kinase with Echelon

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on February 8, 2002
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
277/7/5187    most recent
M110295200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kasai, T.
Right arrow Articles by Jeang, K.-T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kasai, T.
Right arrow Articles by Jeang, K.-T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print November 29, 2001
J. Biol. Chem, 10.1074/jbc.M110295200
Submitted on October 25, 2001
Revised on November 27, 2001
Accepted on November 28, 2001

Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors

Takefumi Kasai, Yoichi Iwanaga, Hidekatsu Iha, and Kuan-Teh Jeang

National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0460

Corresponding Author: kj7e{at}nih.gov

Human T-cell leukemia virus type I (HTLV-I) is the causative agent for adult T-cell leukemia (ATL). Molecularly, ATL cells have extensive aneugenic abnormalities which occur, at least in part, from cell cycle dysregulation by the HTLV-I-encoded Tax oncoprotein. Here, we compared six HTLV-I transformed cells to Jurkat and primary peripheral blood mononuclear cells (PBMC) in their responses to treatment with microtubule inhibitors (MTI). We found that both Jurkat and PBMCs arrested efficiently in mitosis when treated with nocodazole. By contrast, all six HTLV-I cells failed to arrest comparably in mitosis suggesting that ATL cells have a defect in the mitotic spindle assembly checkpoint. Mechanistically, we observed that in HTLV-I Tax-expressing cells human spindle assembly checkpoint factors hsMAD1 and hsMAD2 were mislocated from the nucleus to the cytoplasm. This altered localization of hsMAD1 and hsMAD2 correlated with loss of mitotic checkpoint function and chemoresistance to microtubule inhibitors.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Clin. Pathol.Home page
G P Taylor
Molecular aspects of HTLV-I infection and adult T-cell leukaemia/lymphoma
J. Clin. Pathol., December 1, 2007; 60(12): 1392 - 1396.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. V. Sheleg, J.-M. Peloponese, Y.-H. Chi, Y. Li, M. Eckhaus, and K.-T. Jeang
Evidence for Cooperative Transforming Activity of the Human Pituitary Tumor Transforming Gene and Human T-Cell Leukemia Virus Type 1 Tax
J. Virol., August 1, 2007; 81(15): 7894 - 7901.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Tsuji, N. Sheehy, V. W. Gautier, H. Hayakawa, H. Sawa, and W. W. Hall
The Nuclear Import of the Human T Lymphotropic Virus Type I (HTLV-1) Tax Protein Is Carrier- and Energy-independent
J. Biol. Chem., May 4, 2007; 282(18): 13875 - 13883.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Boyapati, M. Yan, L. F. Peterson, J. R. Biggs, M. M. Le Beau, and D.-E. Zhang
A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidy
Blood, May 1, 2007; 109(9): 3963 - 3971.
[Abstract] [Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
H. Y. Yamada and G. J. Gorbsky
Spindle checkpoint function and cellular sensitivity to antimitotic drugs
Mol. Cancer Ther., December 1, 2006; 5(12): 2963 - 2969.
[Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
G. M. Chin and R. Herbst
Induction of apoptosis by monastrol, an inhibitor of the mitotic kinesin Eg5, is independent of the spindle checkpoint.
Mol. Cancer Ther., October 1, 2006; 5(10): 2580 - 2591.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
Y. Tabakin-Fix, I. Azran, Y. Schavinky-Khrapunsky, O. Levy, and M. Aboud
Functional inactivation of p53 by human T-cell leukemia virus type 1 Tax protein: mechanisms and clinical implications
Carcinogenesis, April 1, 2006; 27(4): 673 - 681.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J.-M. Peloponese Jr., K. Haller, A. Miyazato, and K.-T. Jeang
Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein
PNAS, December 27, 2005; 102(52): 18974 - 18979.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
A. Skladanowski, M.-G. Come, M. Sabisz, A. E. Escargueil, and A. K. Larsen
Down-Regulation of DNA Topoisomerase II{alpha} Leads to Prolonged Cell Cycle Transit in G2 and Early M Phases and Increased Survival to Microtubule-Interacting Agents
Mol. Pharmacol., September 1, 2005; 68(3): 625 - 634.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Matsuoka and K.-T. Jeang
Human T-Cell Leukemia Virus Type I at Age 25: A Progress Report
Cancer Res., June 1, 2005; 65(11): 4467 - 4470.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Vogel, A. Kienitz, R. Muller, and H. Bastians
The Mitotic Spindle Checkpoint Is a Critical Determinant for Topoisomerase-based Chemotherapy
J. Biol. Chem., February 11, 2005; 280(6): 4025 - 4028.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. V. Kibler, A. Miyazato, V. S. R. K. Yedavalli, A. I. Dayton, B. L. Jacobs, G. Dapolito, S.-j. Kim, and K.-T. Jeang
Polyarginine Inhibits gp160 Processing by Furin and Suppresses Productive Human Immunodeficiency Virus Type 1 Infection
J. Biol. Chem., November 19, 2004; 279(47): 49055 - 49063.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J.-M. Peloponese Jr., H. Iha, V. R. K. Yedavalli, A. Miyazato, Y. Li, K. Haller, M. Benkirane, and K.-T. Jeang
Ubiquitination of Human T-Cell Leukemia Virus Type 1 Tax Modulates Its Activity
J. Virol., November 1, 2004; 78(21): 11686 - 11695.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-T. Jeang, C.-z. Giam, F. Majone, and M. Aboud
Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation
J. Biol. Chem., July 30, 2004; 279(31): 31991 - 31994.
[Full Text] [PDF]

Home page
 Molecular Cancer TherapeuticsHome page
M. R. Bani, M. I. Nicoletti, N. W. Alkharouf, C. Ghilardi, D. Petersen, E. Erba, E. A. Sausville, E. T. Liu, and R. Giavazzi
Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts
Mol. Cancer Ther., February 1, 2004; 3(2): 111 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
A. Masuda, K. Maeno, T. Nakagawa, H. Saito, and T. Takahashi
Association between Mitotic Spindle Checkpoint Impairment and Susceptibility to the Induction of Apoptosis by Anti-Microtubule Agents in Human Lung Cancers
Am. J. Pathol., September 1, 2003; 163(3): 1109 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
B. Liu, M.-H. Liang, Y.-l. Kuo, W. Liao, I. Boros, T. Kleinberger, J. Blancato, and C.-Z. Giam
Human T-Lymphotropic Virus Type 1 Oncoprotein Tax Promotes Unscheduled Degradation of Pds1p/Securin and Clb2p/Cyclin B1 and Causes Chromosomal Instability
Mol. Cell. Biol., August 1, 2003; 23(15): 5269 - 5281.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Alefantis, K. Barmak, E. W. Harhaj, C. Grant, and B. Wigdahl
Characterization of a Nuclear Export Signal within the Human T Cell Leukemia Virus Type I Transactivator Protein Tax
J. Biol. Chem., June 6, 2003; 278(24): 21814 - 21822.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Okada and K.-T. Jeang
Differential Requirements for Activation of Integrated and Transiently Transfected Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat
J. Virol., November 13, 2002; 76(24): 12564 - 12573.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.