| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print March 20, 2002
Department of Cardiovascular Medicine, Kyushu University, Fukuoka 812-8582
Corresponding Author: ichiki{at}cardiol.med.kyushu-u.ac.jp
We previously reported an important role of cyclic AMP response element (CRE) for the induction of interleukin-6 gene expression by angiotensin II (AngII). We examined signaling pathways that are responsible for AngII-induced phosphorylation of CRE binding protein (CREB) at serine 133 that is a critical marker for the activation in rat vascular smooth muscle cells (VSMC). AngII time-dependently induced phosphorylation of CREB with a peak at 5 minutes. The AngII-induced phosphorylation of CREB was blocked by CV11974, an AngII type I receptor (AT1-R) antagonist, suggesting that AT1-R may mediate the phosphorylation of CREB. Inhibition of extracellular signal-regulated protein kinase (ERK) by PD98059 or inhibition of p38 mitogen activated protein kinase (MAPK) by SB203580 partially inhibited AngII-induced CREB phosphorylation. A protein kinase A (PKA) inhibitor, H89, also partially suppressed AngII-induced CREB phosphorylation. Inhibition of epidermal growth factor-receptor (EGF-R) by AG1478 suppressed the AngII-induced CREB phosphorylation as well as activation of ERK and p38MAPK. Overexpression of dominant negative form of CREB by an adenovirus vector suppressed AngII-induced c-fos expression and incorporation of [3H]-leucine to VSMC. These findings suggest that AngII may activate multiple signaling pathways involving two MAPK pathways and PKA, all of which contribute to the activation of CREB. Transactivation of EGF-R is also critical for AngII-induced CREB phosphorylation. Activation of CREB may be important for the regulation of gene expression and hypertrophy of VSMC induced by AngII.
J. Biol. Chem, 10.1074/jbc.M110430200
Submitted on October 30, 2001
Revised on March 20, 2002
Accepted on March 20, 2002
Critical role of cAMP response element-binding protein (CREB) for angiotensin II-induced hypertrophy of vascular smooth muscle cells
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Avkiran, A. J. Rowland, F. Cuello, and R. S. Haworth Protein Kinase D in the Cardiovascular System: Emerging Roles in Health and Disease Circ. Res., February 1, 2008; 102(2): 157 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Coles, C. A. Fielding, S. Rose-John, J. Scheller, S. A. Jones, and V. B. O'Donnell Classic Interleukin-6 Receptor Signaling and Interleukin-6 trans-Signaling Differentially Control Angiotensin II-Dependent Hypertension, Cardiac Signal Transducer and Activator of Transcription-3 Activation, and Vascular Hypertrophy in Vivo Am. J. Pathol., July 1, 2007; 171(1): 315 - 325. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-T. Tsai, D. L. Wang, W.-P. Chen, J.-J. Hwang, C.-S. Hsieh, K.-L. Hsu, C.-D. Tseng, L.-P. Lai, Y.-Z. Tseng, F.-T. Chiang, et al. Angiotensin II Increases Expression of {alpha}1C Subunit of L-Type Calcium Channel Through a Reactive Oxygen Species and cAMP Response Element-Binding Protein-Dependent Pathway in HL-1 Myocytes Circ. Res., May 25, 2007; 100(10): 1476 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Shen, L. M. Harrison-Bernard, A. J. Fuller, V. Vanderpool, Z. Saifudeen, and S. S. El-Dahr The Bradykinin B2 Receptor Gene Is a Target of Angiotensin II Type 1 Receptor Signaling J. Am. Soc. Nephrol., April 1, 2007; 18(4): 1140 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Li, H. Yin, Y.-Y. Yao, B. Shen, M. Bader, L. Chao, and J. Chao Tissue kallikrein protects against pressure overload-induced cardiac hypertrophy through kinin B2 receptor and glycogen synthase kinase-3{beta} activation Cardiovasc Res, January 1, 2007; 73(1): 130 - 142. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. V. Garat, D. Fankell, P. F. Erickson, J. E.-B. Reusch, N. N. Bauer, I. F. McMurtry, and D. J. Klemm Platelet-Derived Growth Factor BB Induces Nuclear Export and Proteasomal Degradation of CREB via Phosphatidylinositol 3-Kinase/Akt Signaling in Pulmonary Artery Smooth Muscle Cells. Mol. Cell. Biol., July 1, 2006; 26(13): 4934 - 4948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Dronadula, F. Rizvi, E. Blaskova, Q. Li, and G. N. Rao Involvement of cAMP-response element binding protein-1 in arachidonic acid-induced vascular smooth muscle cell motility J. Lipid Res., April 1, 2006; 47(4): 767 - 777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ichiki Role of cAMP Response Element Binding Protein in Cardiovascular Remodeling: Good, Bad, or Both? Arterioscler. Thromb. Vasc. Biol., March 1, 2006; 26(3): 449 - 455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Najwer and B. Lilly Ca2+/calmodulin-dependent protein kinase IV activates cysteine-rich protein 1 through adjacent CRE and CArG elements Am J Physiol Cell Physiol, October 1, 2005; 289(4): C785 - C793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ortega, D. Ramila, A. Izquierdo, L. Gonzalez, A. Barat, R. Gazapo, R. J. Bosch, and P. Esbrit Role of the Renin-Angiotensin System on the Parathyroid Hormone-Related Protein Overexpression Induced by Nephrotoxic Acute Renal Failure in the Rat J. Am. Soc. Nephrol., April 1, 2005; 16(4): 939 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ono, T. Ichiki, K. Fukuyama, N. Iino, S. Masuda, K. Egashira, and A. Takeshita cAMP-Response Element-Binding Protein Mediates Tumor Necrosis Factor-{alpha}-Induced Vascular Smooth Muscle Cell Migration Arterioscler. Thromb. Vasc. Biol., September 1, 2004; 24(9): 1634 - 1639. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tokudome, T. Horio, M. Fukunaga, H. Okumura, J. Hino, K. Mori, F. Yoshihara, S.-I. Suga, Y. Kawano, M. Kohno, et al. Ventricular Nonmyocytes Inhibit Doxorubicin-Induced Myocyte Apoptosis: Involvement of Endogenous Endothelin-1 as a Paracrine Factor Endocrinology, May 1, 2004; 145(5): 2458 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tan, F. N. Hutchison, and A. A. Jaffa Mechanisms of angiotensin II-induced expression of B2 kinin receptors Am J Physiol Heart Circ Physiol, March 1, 2004; 286(3): H926 - H932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Tokunou, R. Shibata, H. Kai, T. Ichiki, T. Morisaki, K. Fukuyama, H. Ono, N. Iino, S. Masuda, H. Shimokawa, et al. Apoptosis Induced by Inhibition of Cyclic AMP Response Element-Binding Protein in Vascular Smooth Muscle Cells Circulation, September 9, 2003; 108(10): 1246 - 1252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ichiki, T. Tokunou, K. Fukuyama, N. Iino, S. Masuda, and A. Takeshita Cyclic AMP Response Element-Binding Protein Mediates Reactive Oxygen Species-Induced c-fos Expression Hypertension, August 1, 2003; 42(2): 177 - 183. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
