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Papers In Press, published online ahead of print December 10, 2001
J. Biol. Chem, 10.1074/jbc.M110615200
Submitted on November 5, 2001
Revised on November 30, 2001
Accepted on December 10, 2001
Molecular and Cell Biology, University of California, Berkeley, CA 94720-3206
Corresponding Author: slinn{at}socrates.berkeley.edu
DNA polymerase epsilon (pol 
) has been implicated in DNA replication, DNA repair, and cell cycle control, but its precise roles are unclear. When the subcellular localization of human pol was examined by indirect immunofluorescence, pol appeared in discrete nuclear foci that colocalized with PCNA foci and sites of DNA synthesis only late in S phase. Early in S phase, pol foci were adjacent to PCNA foci. In contrast to PCNA foci that were only present in S phase, pol foci were present throughout mitosis and the G1 phase of cycling cells. It is hypothesized from these observations that pol and PCNA have separate, but associated functions early in S phase and that pol participates with PCNA in DNA replication late in S phase.
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