| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print January 11, 2002
J. Biol. Chem, 10.1074/jbc.M110747200
Submitted on November 8, 2001
Revised on January 9, 2002
Accepted on January 11, 2002
Division of Gastroenterology, New England Medical Center, Boston, MA 02111
Corresponding Author: aleiter{at}lifespan.org
Expression of the hormone secretin in enteroendocrine cells is restricted to the nondividing villus compartment of the intestine, implying that terminal differentiation is linked to cell cycle arrest and that differentiation is repressed in actively proliferating cells. We have previously shown that the basic helix loop helix protein, BETA2/NeuroD induces cell cycle withdrawal in addition to increasing secretin gene expression. A number of transcription factors important for differentiation are repressed by D cyclins. Repression by D cyclins appears to be independent of its effects on the cell cycle. Here we show that cyclin D1 represses BETA2/NeuroD dependent transcription of the secretin gene. Examination of cyclin box mutants shows that repression is unrelated ability to activate Cdk4. Although cyclin D1 and BETA2 associate in vivo, they do not directly interact. Cyclin D1 may be recruited to BETA2 by binding to the C terminal domain of the p300 coactivator, downstream from the BETA2 binding site. In the small intestine, cyclin D1 expression occurs only in the actively proliferating crypts of Lieberkuhn but not in villi. Thus repression by cyclin D1 may serve to prevent secretin gene transcription from occurring in relatively immature epithelial progenitor cells.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  H.-W. Wang, M. Muguira, W.-D. Liu, T. Zhang, C. Chen, R. Aucoin, M. B Breslin, and M. S Lan Identification of an INSM1-binding site in the insulin promoter: negative regulation of the insulin gene transcription J. Endocrinol., July 1, 2008; 198(1): 29 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. Ray and A. B. Leiter The Basic Helix-Loop-Helix Transcription Factor NeuroD1 Facilitates Interaction of Sp1 with the Secretin Gene Enhancer Mol. Cell. Biol., November 15, 2007; 27(22): 7839 - 7847. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fu, C. Wang, M. Rao, X. Wu, T. Bouras, X. Zhang, Z. Li, X. Jiao, J. Yang, A. Li, et al. Cyclin D1 Represses p300 Transactivation through a Cyclin-dependent Kinase-independent Mechanism J. Biol. Chem., August 19, 2005; 280(33): 29728 - 29742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fu, M. Rao, T. Bouras, C. Wang, K. Wu, X. Zhang, Z. Li, T.-P. Yao, and R. G. Pestell Cyclin D1 Inhibits Peroxisome Proliferator-activated Receptor {gamma}-mediated Adipogenesis through Histone Deacetylase Recruitment J. Biol. Chem., April 29, 2005; 280(17): 16934 - 16941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Batsche, P. Moschopoulos, J. Desroches, S. Bilodeau, and J. Drouin Retinoblastoma and the Related Pocket Protein p107 Act as Coactivators of NeuroD1 to Enhance Gene Transcription J. Biol. Chem., April 22, 2005; 280(16): 16088 - 16095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Liu and R. M. Harland Inhibition of neurogenesis by SRp38, a neuroD-regulated RNA-binding protein Development, April 1, 2005; 132(7): 1511 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, J. P. Gaspard, Y. Mizukami, J. Li, F. Graeme-Cook, and D. C. Chung Overexpression of Cyclin D1 in Pancreatic {beta}-Cells In Vivo Results in Islet Hyperplasia Without Hypoglycemia Diabetes, March 1, 2005; 54(3): 712 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Fu, C. Wang, Z. Li, T. Sakamaki, and R. G. Pestell Minireview: Cyclin D1: Normal and Abnormal Functions Endocrinology, December 1, 2004; 145(12): 5439 - 5447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Emmerich, C. A. Meyer, A. F. A. de la Cruz, B. A. Edgar, and C. F. Lehner Cyclin D Does Not Provide Essential Cdk4-Independent Functions in Drosophila Genetics, October 1, 2004; 168(2): 867 - 875. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Kanamoto, T. Akamizu, T. Tagami, Y. Hataya, K. Moriyama, K. Takaya, H. Hosoda, M. Kojima, K. Kangawa, and K. Nakao Genomic Structure and Characterization of the 5'-Flanking Region of the Human Ghrelin Gene Endocrinology, September 1, 2004; 145(9): 4144 - 4153. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Ray, J. Nishitani, M. W. Petry, M. Y. Fessing, and A. B. Leiter Novel Transcriptional Potentiation of BETA2/NeuroD on the Secretin Gene Promoter by the DNA-Binding Protein Finb/RREB-1 Mol. Cell. Biol., January 1, 2003; 23(1): 259 - 271. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
