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Papers In Press, published online ahead of print December 31, 2001
J. Biol. Chem, 10.1074/jbc.M110849200
Submitted on November 12, 2001
Revised on December 31, 2001
Accepted on December 31, 2001

Role of the Ada2 and Ada3 transcriptional coactivators in histone acetylation

Ramakrishnan Balasubramanian, Marilyn G. Pray-Grant, William Selleck, Patrick A. Grant, and Song Tan

Biochemistry & Molecular Biology, Penn State, University Park, PA 16802

Corresponding Author: sxt30{at}psu.edu

Previous studies have shown that the transcriptional coactivator protein Gcn5/Ada4 functions as a catalytic histone acetyltransferase (HAT). In this work, we examine the roles of the Ada2 and Ada3 coactivator proteins which are functionally linked to Gcn5. We show that yeast Ada2, Ada3 and Gcn5 form a catalytic core of the ADA and SAGA HAT complexes which is necessary and sufficient in vitro for nucleosomal HAT activity and lysine specificity of the intact HAT complexes. We also demonstrate that Ada3 is necessary for Gcn5-dependent nucleosomal HAT activity in yeast extracts. Our results suggest that Ada2 potentiates Gcn5's catalytic activity and that Ada3 facilitates nucleosomal acetylation and an expanded lysine specificity.


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