|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print December 27, 2001
Department of Dermatology, J507, Boston University School of Medicine, Boston, MA 02118-2394
Corresponding Author: bgilchre{at}bu.edu
p75NTR, a nerve growth factor co-receptor that has been implicated in apoptosis of neurons, is structurally related to Fas and the receptors for tumor necrosis factor-a that display ligand independent assembly into trimers. Using E17 fetal rat cortical neurons and p75NTR expressing NIH-3T3 cells, we now show that p75NTR exists as a trimer as well as a monomer. Furthermore, we have reported and others have confirmed that amyloid b binds p75NTR, and that this binding leads to apoptotic cell death. We now report that amyloid b binds to trimers of p75NTR as well as to p75NTR monomers but not to the p140trkA, the nerve growth factor co-receptor that mediates neuronal survival. Furthermore, amyloid b activates p75NTR, strongly inducing the transcription of c-jun mRNA and stimulating the stress-activated c-Jun NH2-terminal kinase (JNK) as measured by phosphorylation of its substrate [GST-c-Jun (1-79)]. Our data suggest that p75NTR may be present as a preformed trimer that binds amyloid â to induce receptor activation, and support the hypothesis that p75NTR activation by amyloid â is causally related to Alzheimer’s disease.
J. Biol. Chem, 10.1074/jbc.M110929200
Submitted on November 14, 2001
Revised on December 27, 2001
Accepted on December 27, 2001
Beta amyloid binds trimers as well as monomers of the 75 kD neurotrophin receptor and activates receptor signaling
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. G. Bengoechea, Z. Chen, D. O'Leary, E. Masliah, and K.-F. Lee p75 reduces {beta}-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model PNAS, May 12, 2009; 106(19): 7870 - 7875. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-J. Hsu, C. Y. Hsu, B.-C. Chen, M.-C. Chen, G. Ou, and C.-H. Lin Apoptosis Signal-Regulating Kinase 1 in Amyloid {beta} Peptide-Induced Cerebral Endothelial Cell Apoptosis J. Neurosci., May 23, 2007; 27(21): 5719 - 5729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Yamamoto, E. Matsubara, S. Maeda, H. Minagawa, A. Takashima, W. Maruyama, M. Michikawa, and K. Yanagisawa A Ganglioside-induced Toxic Soluble Abeta Assembly: ITS ENHANCED FORMATION FROM AbetaBEARING THE ARCTIC MUTATION J. Biol. Chem., January 26, 2007; 282(4): 2646 - 2655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Podlesniy, A. Kichev, C. Pedraza, J. Saurat, M. Encinas, B. Perez, I. Ferrer, and C. Espinet Pro-NGF from Alzheimer's Disease and Normal Human Brain Displays Distinctive Abilities to Induce Processing and Nuclear Translocation of Intracellular Domain of p75NTR and Apoptosis Am. J. Pathol., July 1, 2006; 169(1): 119 - 131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. L. Malinin, S. Wright, P. Seubert, D. Schenk, and I. Griswold-Prenner Amyloid-{beta} neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity PNAS, February 22, 2005; 102(8): 3058 - 3063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Pedraza, P. Podlesniy, N. Vidal, J. C. Arevalo, R. Lee, B. Hempstead, I. Ferrer, M. Iglesias, and C. Espinet Pro-NGF Isolated from the Human Brain Affected by Alzheimer's Disease Induces Neuronal Apoptosis Mediated by p75NTR Am. J. Pathol., February 1, 2005; 166(2): 533 - 543. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. B. Patel Single Transmembrane Spanning Heterotrimeric G Protein-Coupled Receptors and Their Signaling Cascades Pharmacol. Rev., September 1, 2004; 56(3): 371 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. BREDESEN, P. MEHLEN, and S. RABIZADEH Apoptosis and Dependence Receptors: A Molecular Basis for Cellular Addiction Physiol Rev, April 1, 2004; 84(2): 411 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mehlen and D. E. Bredesen Meeting Report: Cellular Dependence--Old Concept, New Mechanisms Sci. Signal., December 16, 2003; 2003 (213): pe55 - pe55. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Chao Dependence Receptors: What Is the Mechanism? Sci. Signal., September 16, 2003; 2003(200): pe38 - pe38. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, Y. Hong, Y. Bounhar, M. Blacker, X. Roucou, O. Tounekti, E. Vereker, W. J. Bowers, H. J. Federoff, C. G. Goodyer, et al. p75 Neurotrophin Receptor Protects Primary Cultures of Human Neurons against Extracellular Amyloid {beta} Peptide Cytotoxicity J. Neurosci., August 13, 2003; 23(19): 7385 - 7394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Dobransky, D. Brewer, G. Lajoie, and R. J. Rylett Phosphorylation of 69-kDa Choline Acetyltransferase at Threonine 456 in Response to Amyloid-beta Peptide 1-42 J. Biol. Chem., February 14, 2003; 278(8): 5883 - 5893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Redwine, B. Kosofsky, R. E. Jacobs, D. Games, J. F. Reilly, J. H. Morrison, W. G. Young, and F. E. Bloom Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: A magnetic resonance microscopy and stereologic analysis PNAS, February 4, 2003; 100(3): 1381 - 1386. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Langevin, H. Jaaro, S. Bressanelli, M. Fainzilber, and C. Tuffereau Rabies Virus Glycoprotein (RVG) Is a Trimeric Ligand for the N-terminal Cysteine-rich Domain of the Mammalian p75 Neurotrophin Receptor J. Biol. Chem., September 27, 2002; 277(40): 37655 - 37662. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |