| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print May 15, 2002
Dept. of Biochemistry and Molecular Biology, University of Southern Denmark, Odense M 5230
Corresponding Author: s.mandrup{at}bmb.sdu.dk
The acyl-CoA binding protein (ACBP) is a 10 kD intracellular protein that specifically binds acyl-CoA esters with high affinity and is structurally and functionally conserved from yeast to mammals. In vitro studies indicate that ACBP may regulate the availability of acyl-CoA esters for various metabolic and regulatory purposes. The protein is particularly abundant in cells with a high level of lipogenesis and de novo fatty acid synthesis and is significantly induced during adipocyte differentiation. However, the molecular mechanisms underlying the regulation of ACBP expression in mammalian cells have remained largely unknown. Here we report that ACBP is a novel PPAR
J. Biol. Chem, 10.1074/jbc.M111295200
Submitted on November 27, 2001
Revised on May 14, 2002
Accepted on May 14, 2002
The gene encoding the acyl-CoA binding protein is activated by peroxisome proliferator activated receptor
through an intronic response element functionally conserved between man and rodents
target gene. The rat ACBP gene is directly activated by PPAR/RXR
and PPAR/RXR, but not by PPAR
/RXR, through a PPAR response element in intron 1, which is functionally conserved in the human ACBP gene. The intronic PPRE mediates induction by endogenous PPAR in murine adipocytes and confers responsiveness to the PPAR selective ligand BRL49653. Finally, we have used chromatin immunoprecipitation to demonstrate that the intronic PPRE efficiently binds PPAR/RXR in its natural chromatin context in adipocytes. Thus, the PPRE in intron 1 of the ACBP gene is a bone fide PPAR response element.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. E. Kershaw, M. Schupp, H.-P. Guan, N. P. Gardner, M. A. Lazar, and J. S. Flier PPAR{gamma} regulates adipose triglyceride lipase in adipocytes in vitro and in vivo Am J Physiol Endocrinol Metab, December 1, 2007; 293(6): E1736 - E1745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Islinger, G. H. Luers, K. W. Li, M. Loos, and A. Volkl Rat Liver Peroxisomes after Fibrate Treatment: A SURVEY USING QUANTITATIVE MASS SPECTROMETRY J. Biol. Chem., August 10, 2007; 282(32): 23055 - 23069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ying, O. Araki, F. Furuya, Y. Kato, and S.-Y. Cheng Impaired Adipogenesis Caused by a Mutated Thyroid Hormone {alpha}1 Receptor Mol. Cell. Biol., March 15, 2007; 27(6): 2359 - 2371. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Atshaves, A. L. McIntosh, D. Landrock, H. R. Payne, J. T. Mackie, N. Maeda, J. Ball, F. Schroeder, and A. B. Kier Effect of SCP-x gene ablation on branched-chain fatty acid metabolism Am J Physiol Gastrointest Liver Physiol, March 1, 2007; 292(3): G939 - G951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Nielsen, L. Grontved, H. G. Stunnenberg, and S. Mandrup Peroxisome Proliferator-Activated Receptor Subtype- and Cell-Type-Specific Activation of Genomic Target Genes upon Adenoviral Transgene Delivery Mol. Cell. Biol., August 1, 2006; 26(15): 5698 - 5714. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-W. Chang, R. Nagarajan, J. A. Magee, J. Milbrandt, and G. D. Stormo A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles Genome Res., March 1, 2006; 16(3): 405 - 413. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Araki, H. Ying, F. Furuya, X. Zhu, and S.-y. Cheng Thyroid hormone receptor {beta} mutants: Dominant negative regulators of peroxisome proliferator-activated receptor {gamma} action PNAS, November 8, 2005; 102(45): 16251 - 16256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sironi, G. Menozzi, G. P. Comi, R. Cagliani, N. Bresolin, and U. Pozzoli Analysis of intronic conserved elements indicates that functional complexity might represent a major source of negative selection on non-coding sequences Hum. Mol. Genet., September 1, 2005; 14(17): 2533 - 2546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Atshaves, A. L. McIntosh, H. R. Payne, J. Mackie, A. B. Kier, and F. Schroeder Effect of branched-chain fatty acid on lipid dynamics in mice lacking liver fatty acid binding protein gene Am J Physiol Cell Physiol, March 1, 2005; 288(3): C543 - C558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Sandberg, M. Bloksgaard, D. Duran-Sandoval, C. Duval, B. Staels, and S. Mandrup The Gene Encoding Acyl-CoA-binding Protein Is Subject to Metabolic Regulation by Both Sterol Regulatory Element-binding Protein and Peroxisome Proliferator-activated Receptor {alpha} in Hepatocytes J. Biol. Chem., February 18, 2005; 280(7): 5258 - 5266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ohnishi, H. Koshino, S. Takahashi, Y. Esumi, and S. Matsumoto Isolation and Characterization of a Humoral Factor That Stimulates Transcription of the Acyl-CoA-binding Protein in the Pheromone Gland of the Silkmoth, Bombyx mori J. Biol. Chem., February 11, 2005; 280(6): 4111 - 4116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shimizu, A. Takeshita, T. Tsukamoto, F. J. Gonzalez, and T. Osumi Tissue-Selective, Bidirectional Regulation of PEX11{alpha} and Perilipin Genes through a Common Peroxisome Proliferator Response Element Mol. Cell. Biol., February 1, 2004; 24(3): 1313 - 1323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kikuchi, N. Hatano, S. Yokota, N. Shimozawa, T. Imanaka, and H. Taniguchi Proteomic Analysis of Rat Liver Peroxisome: PRESENCE OF PEROXISOME-SPECIFIC ISOZYME OF LON PROTEASE J. Biol. Chem., January 2, 2004; 279(1): 421 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Brown and M. K. McIntosh Conjugated Linoleic Acid in Humans: Regulation of Adiposity and Insulin Sensitivity J. Nutr., October 1, 2003; 133(10): 3041 - 3046. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C. Pircher, J. L. Kitto, M. L. Petrowski, R. K. Tangirala, E. D. Bischoff, I. G. Schulman, and S. K. Westin Farnesoid X Receptor Regulates Bile Acid-Amino Acid Conjugation J. Biol. Chem., July 18, 2003; 278(30): 27703 - 27711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Brown, M. S. Boysen, S. S. Jensen, R. F. Morrison, J. Storkson, R. Lea-Currie, M. Pariza, S. Mandrup, and M. K. McIntosh Isomer-specific regulation of metabolism and PPAR{gamma} signaling by CLA in human preadipocytes J. Lipid Res., July 1, 2003; 44(7): 1287 - 1300. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
