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Papers In Press, published online ahead of print January 15, 2002
J. Biol. Chem, 10.1074/jbc.M111391200
Submitted on November 29, 2001
Revised on January 11, 2002
Accepted on January 14, 2002

Characterization of a novel salivary immunosuppressive protein from Ixodes ricinus ticks

Gérard Leboulle, Mara Crippa, Yves Decrem, Naceur Mejri, Michel Brossard, Alex Bollen, and Edmond Godfroid

Department of Applied Genetics, Université Libre de Bruxelles, Gosselies B-6041

Corresponding Author: godfroid{at}sga.ulb.ac.be

In tick salivary glands, several genes are induced during the feeding process leading to the expression of new proteins. These proteins are typically secreted in tick saliva and are potentially involved in the modulation of the host immune and haemostatic responses. In a previous study, the construction and the analysis of a subtractive library led to the identification of Ixodes ricinus immunosuppressor (Iris), a novel protein, differentially expressed in I. ricinus salivary glands during the blood meal. In the present study, we show that this protein is secreted by tick salivary glands into the saliva. Iris is also found to modulate T lymphocyte and macrophage responsiveness by inducing a Th2 type response and by inhibiting the production of pro-inflammatory cytokines. In conclusion, these results infer that Iris is a immunosuppressor, which may play an important role in the modulation of host immune response.


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