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Papers In Press, published online ahead of print January 30, 2002
Department of Microbiology, University of Minnesota, Minneapolis, MN 55455
Corresponding Author: pats{at}lenti.med.umn.edu
We describe the complete map of the 15.9-kilobase pair staphylococcal pathogenicity island 3 encoding staphylococcal enterotoxin serotypes B, K and Q. The island, which meets the generally accepted definition of pathogenicity islands, contains 24 open reading frames potentially encoding proteins of more than 50 amino acids, including an apparently functional integrase. The element is bordered by two 17-base pair direct repeats identical to those found flanking staphylococcal pathogenicity island 1. The island has extensive regions of homology to previously described pathogenicity islands, particularly staphylococcal pathogenicity islands 1 and bov. The expression of 22 of the 24 open reading frames contained on staphylococcal pathogenicity island 3 was detected either in vitro during growth in a laboratory medium or serum, or in vivo in a rabbit model of toxic shock syndrome using DNA microarrays. The effect of oxygen tension on staphylococcal pathogenicity island 3 gene expression was also examined. By comparison of the known staphylococcal pathogenicity islands in the context of gene expression described here, we propose a model of pathogenicity island origin and evolution involving specialized transduction events and addition, deletion, or recombination of pathogenicity island “modules”.
J. Biol. Chem, 10.1074/jbc.M111661200
Submitted on December 6, 2001
Revised on January 30, 2002
Accepted on January 29, 2002
Characterization and expression analysis of Staphylococcus aureus pathogenicity island 3: implications for the evolution of staphylococcal pathogenicity islands
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