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M201267200v1
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Papers In Press, published online ahead of print April 8, 2002
J. Biol. Chem, 10.1074/jbc.M201267200
Submitted on February 7, 2002
Revised on April 8, 2002
Accepted on April 5, 2002

A novel non-conventional heat shock element regulates expression of MDJ1 encoding a DnaJ homolog in Saccharomyces cerevisiae

Tomohusa Tachibana, Shiho Astumi, Ryo Shioda, Masaru Ueno, Masahiro Uritani, and Takashi Ushimaru

Faculty of Science, Shizuoka University, Shizuoka, Shizuoka 422-8529

Corresponding Author: sbtushi{at}ipc.shizuoka.ac.jp

The heat shock factor (HSF) is a pivotal transcriptional factor that regulates expression of genes encoding heat shock proteins (HSPs) via heat shock elements (HSEs). "nGAAnnTTCnnGAAn" functions as the minimum consensus HSE (cHSE) in vivo. Here we show that expression of Saccharomyces cerevisiae MDJ1, encoding a mitochondrial DnaJ homolog, is regulated by HSF via a novel non-consensus HSE (ncHSEMDJ1), which consists of three separated pentameric "nGAAn" motifs, "nTTCn-(11 bp)-nGAAn-(5 bp)-nGAAn". This is the first evidence to show that the immediate contact of "nGAAn" motifs is dispensable for regulation by HSF in vivo. ncHSEMDJ1 confers different heat shock responses versus cHSE and unlike cHSE, definitively requires a carboxyl-terminal activation domain of HSF in the expression. ncHSEMDJ1-like elements are found in promoter regions of some other DnaJ-related genes. The highly conserved HSF/HSE system suggests that similar ncHSEs may be used for expression of HSP genes in other eukaryotes, including humans.


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