| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print April 10, 2002
J. Biol. Chem, 10.1074/jbc.M202390200
Submitted on March 12, 2002
Revised on April 8, 2002
Accepted on April 9, 2002
Centre National de la Recherche Scientifique, UPR 9003 Ecole Supérieure de Biotechnologie de Strasbourg, Illkirch-Graffenstaden F-67400
Corresponding Author: schreibe{at}esbs.u-strasbg.fr
The DNA damage-dependency of poly(ADP-ribose) polymerase-2 (PARP-2) activity is suggestive of its implication in genome surveillance and protection. Here we show that the PARP-2 gene, mainly expressed in actively dividing tissues follows, but to a smaller extend, that of PARP-1 during mouse development. We found that PARP-2 and PARP-1 homo- and heterodimerize; the interacting interfaces, sites of reciprocal modification have been mapped. PARP-2 was also found to interact with three other proteins involved in the base excision repair (BER) pathway: XRCC1, DNA polymerase ß and DNA ligase III, already known as partners of PARP-1. XRCC1 negatively regulates PARP-2 activity, as it does for PARP-1, while being a polymer acceptor for both PARP-1 and PARP-2. To gain insight into the physiological role of PARP-2 in response to genotoxic stress, we developed by gene disruption mice deficient in PARP-2. Following treatment by the alkylating agent MNU, PARP-2 deficient cells displayed an important delay in DNA strand breaks resealing, similar to that observed in PARP-1 deficient cells, thus confirming that PARP-2 is also an active player in base excision repair despite its low capacity to synthesize ADP-ribose polymers.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M.-F. Langelier, K. M. Servent, E. E. Rogers, and J. M. Pascal A Third Zinc-binding Domain of Human Poly(ADP-ribose) Polymerase-1 Coordinates DNA-dependent Enzyme Activation J. Biol. Chem., February 15, 2008; 283(7): 4105 - 4114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Paul, D. W. Melton, and P. T.K. Saunders Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility? Mol. Hum. Reprod., January 1, 2008; 14(1): 1 - 8. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Mateuca, M. Roelants, G. Iarmarcovai, P. V. Aka, L. Godderis, A. Tremp, S. Bonassi, M. Fenech, J.-L. Berge-Lefranc, and M. Kirsch-Volders hOGG1326, XRCC1399 and XRCC3241 polymorphisms influence micronucleus frequencies in human lymphocytes in vivo Mutagenesis, January 1, 2008; 23(1): 35 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Bai, S. M. Houten, A. Huber, V. Schreiber, M. Watanabe, B. Kiss, G. de Murcia, J. Auwerx, and J. M.-d. Murcia Peroxisome Proliferator-activated Receptor (PPAR)-2 Controls Adipocyte Differentiation and Adipose Tissue Function through the Regulation of the Activity of the Retinoid X Receptor/PPAR{gamma} Heterodimer J. Biol. Chem., December 28, 2007; 282(52): 37738 - 37746. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Fahrer, R. Kranaster, M. Altmeyer, A. Marx, and A. Burkle Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length Nucleic Acids Res., December 18, 2007; 35(21): e143 - e143. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Beneke and A. Burkle Poly(ADP-ribosyl)ation in mammalian ageing Nucleic Acids Res., December 3, 2007; 35(22): 7456 - 7465. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Mortusewicz, J.-C. Ame, V. Schreiber, and H. Leonhardt Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells Nucleic Acids Res., December 3, 2007; 35(22): 7665 - 7675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Wacker, D. D. Ruhl, E. H. Balagamwala, K. M. Hope, T. Zhang, and W. L. Kraus The DNA Binding and Catalytic Domains of Poly(ADP-Ribose) Polymerase 1 Cooperate in the Regulation of Chromatin Structure and Transcription Mol. Cell. Biol., November 1, 2007; 27(21): 7475 - 7485. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tramontano, M. Malanga, and P. Quesada Differential contribution of poly(ADP-ribose)polymerase-1 and -2 (PARP-1 and -2) to the poly(ADP-ribosyl)ation reaction in rat primary spermatocytes Mol. Hum. Reprod., November 1, 2007; 13(11): 821 - 828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. O. Fisher, H. Hochegger, S. Takeda, and K. W. Caldecott Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase Mol. Cell. Biol., August 1, 2007; 27(15): 5597 - 5605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Goenka, S. H. Cho, and M. Boothby Collaborator of Stat6 (CoaSt6)-associated Poly(ADP-ribose) Polymerase Activity Modulates Stat6-dependent Gene Transcription J. Biol. Chem., June 29, 2007; 282(26): 18732 - 18739. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Albert, C. Cao, K. W. Kim, C. D. Willey, L. Geng, D. Xiao, H. Wang, A. Sandler, D. H. Johnson, A. D. Colevas, et al. Inhibition of Poly(ADP-Ribose) Polymerase Enhances Cell Death and Improves Tumor Growth Delay in Irradiated Lung Cancer Models Clin. Cancer Res., May 15, 2007; 13(10): 3033 - 3042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Donawho, Y. Luo, Y. Luo, T. D. Penning, J. L. Bauch, J. J. Bouska, V. D. Bontcheva-Diaz, B. F. Cox, T. L. DeWeese, L. E. Dillehay, et al. ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models Clin. Cancer Res., May 1, 2007; 13(9): 2728 - 2737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Suzuki, T. Nishi, T. Nagino, K. Sasaki, K. Aizawa, N. Kada, D. Sawaki, Y. Munemasa, T. Matsumura, S. Muto, et al. Functional Interaction between the Transcription Factor Kruppel-like Factor 5 and Poly(ADP-ribose) Polymerase-1 in Cardiovascular Apoptosis J. Biol. Chem., March 30, 2007; 282(13): 9895 - 9901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ratnam and J. A. Low Current Development of Clinical Inhibitors of Poly(ADP-Ribose) Polymerase in Oncology Clin. Cancer Res., March 1, 2007; 13(5): 1383 - 1388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Keil, T. Grobe, and S. Li Oei MNNG-induced Cell Death Is Controlled by Interactions between PARP-1, Poly(ADP-ribose) Glycohydrolase, and XRCC1 J. Biol. Chem., November 10, 2006; 281(45): 34394 - 34405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Dantzer, M. Mark, D. Quenet, H. Scherthan, A. Huber, B. Liebe, L. Monaco, A. Chicheportiche, P. Sassone-Corsi, G. de Murcia, et al. Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis PNAS, October 3, 2006; 103(40): 14854 - 14859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. O. Hassa, S. S. Haenni, M. Elser, and M. O. Hottiger Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going? Microbiol. Mol. Biol. Rev., September 1, 2006; 70(3): 789 - 829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Tentori, C. Leonetti, M. Scarsella, A. Muzi, E. Mazzon, M. Vergati, O. Forini, R. Lapidus, W. Xu, A. S. Dorio, et al. Inhibition of poly(ADP-ribose) polymerase prevents irinotecan-induced intestinal damage and enhances irinotecan/temozolomide efficacy against colon carcinoma FASEB J, August 1, 2006; 20(10): 1709 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Puebla-Osorio, D. B. Lacey, F. W. Alt, and C. Zhu Early Embryonic Lethality Due to Targeted Inactivation of DNA Ligase III Mol. Cell. Biol., May 15, 2006; 26(10): 3935 - 3941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Maeda, T. C. Hunter, D. E. Loudy, V. Dave, V. Schreiber, and J. A. Whitsett PARP-2 Interacts with TTF-1 and Regulates Expression of Surfactant Protein-B J. Biol. Chem., April 7, 2006; 281(14): 9600 - 9606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gomez, J. Wu, V. Schreiber, J. Dunlap, F. Dantzer, Y. Wang, and Y. Liu PARP1 Is a TRF2-associated Poly(ADP-Ribose)Polymerase and Protects Eroded Telomeres Mol. Biol. Cell, April 1, 2006; 17(4): 1686 - 1696. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Baumann, G. S. Boehden, A. Burkle, and L. Wiesmuller Poly(ADP-RIBOSE) polymerase-1 (Parp-1) antagonizes topoisomerase I-dependent recombination stimulation by P53 Nucleic Acids Res., February 9, 2006; 34(3): 1036 - 1049. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Levy, A. Martz, A. Bresson, C. Spenlehauer, G. de Murcia, and J. Menissier-de Murcia XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage Nucleic Acids Res., January 5, 2006; 34(1): 32 - 41. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Monaco, U. Kolthur-Seetharam, R. Loury, J. M.-d. Murcia, G. de Murcia, and P. Sassone-Corsi Inhibition of Aurora-B kinase activity by poly(ADP-ribosyl)ation in response to DNA damage PNAS, October 4, 2005; 102(40): 14244 - 14248. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Y. Kim, T. Zhang, and W. L. Kraus Poly(ADP-ribosyl)ation by PARP-1: `PAR-laying' NAD+ into a nuclear signal Genes & Dev., September 1, 2005; 19(17): 1951 - 1967. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Yi, S. Li, X. Chen, E. A.C. Wiemer, J. Wang, N. Wei, and X. W. Deng Major Vault Protein, in Concert with Constitutively Photomorphogenic 1, Negatively Regulates c-Jun-Mediated Activator Protein 1 Transcription in Mammalian Cells Cancer Res., July 1, 2005; 65(13): 5835 - 5840. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Brem and J. Hall XRCC1 is required for DNA single-strand break repair in human cells Nucleic Acids Res., May 2, 2005; 33(8): 2512 - 2520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Yu, W. D. Shannon, M. A. Watson, and H. L. McLeod Gene Expression Profiling of the Irinotecan Pathway in Colorectal Cancer Clin. Cancer Res., March 1, 2005; 11(5): 2053 - 2062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Okano, L. Lan, A. E. Tomkinson, and A. Yasui Translocation of XRCC1 and DNA ligase III{alpha} from centrosomes to chromosomes in response to DNA damage in mitotic human cells Nucleic Acids Res., January 14, 2005; 33(1): 422 - 429. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sossou, C. Flohr-Beckhaus, I. Schulz, F. Daboussi, B. Epe, and J. P. Radicella APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability Nucleic Acids Res., January 12, 2005; 33(1): 298 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. S. Meder, M. Boeglin, G. de Murcia, and V. Schreiber PARP-1 and PARP-2 interact with nucleophosmin/B23 and accumulate in transcriptionally active nucleoli J. Cell Sci., January 1, 2005; 118(1): 211 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang, S.-W. Yu, D. W. Koh, J. Lew, C. Coombs, W. Bowers, H. J. Federoff, G. G. Poirier, T. M. Dawson, and V. L. Dawson Apoptosis-Inducing Factor Substitutes for Caspase Executioners in NMDA-Triggered Excitotoxic Neuronal Death J. Neurosci., December 1, 2004; 24(48): 10963 - 10973. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Lan, S. Nakajima, Y. Oohata, M. Takao, S. Okano, M. Masutani, S. H. Wilson, and A. Yasui In situ analysis of repair processes for oxidative DNA damage in mammalian cells PNAS, September 21, 2004; 101(38): 13738 - 13743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. von Kobbe, J. A. Harrigan, V. Schreiber, P. Stiegler, J. Piotrowski, L. Dawut, and V. A. Bohr Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein Nucleic Acids Res., August 3, 2004; 32(13): 4003 - 4014. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, B. E. Snow, V. A. Kickhoefer, N. Erdmann, W. Zhou, A. Wakeham, M. Gomez, L. H. Rome, and L. Harrington Vault Poly(ADP-Ribose) Polymerase Is Associated with Mammalian Telomerase and Is Dispensable for Telomerase Function and Vault Structure In Vivo Mol. Cell. Biol., June 15, 2004; 24(12): 5314 - 5323. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Fan, M. Otterlei, H.-K. Wong, A. E. Tomkinson, and D. M. Wilson III XRCC1 co-localizes and physically interacts with PCNA Nucleic Acids Res., April 23, 2004; 32(7): 2193 - 2201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rouleau, R. A. Aubin, and G. G. Poirier Poly(ADP-ribosyl)ated chromatin domains: access granted J. Cell Sci., February 22, 2004; 117(6): 815 - 825. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Dantzer, M.-J. Giraud-Panis, I. Jaco, J.-C. Ame, I. Schultz, M. Blasco, C.-E. Koering, E. Gilson, J. Menissier-de Murcia, G. de Murcia, et al. Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2 Mol. Cell. Biol., February 15, 2004; 24(4): 1595 - 1607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Malanga and F. R. Althaus Poly(ADP-ribose) Reactivates Stalled DNA Topoisomerase I and Induces DNA Strand Break Resealing J. Biol. Chem., February 13, 2004; 279(7): 5244 - 5248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Oliver, J.-C. Ame, S. M. Roe, V. Good, G. de Murcia, and L. H. Pearl Crystal structure of the catalytic fragment of murine poly(ADP-ribose) polymerase-2 Nucleic Acids Res., January 22, 2004; 32(2): 456 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. von Kobbe, J. A. Harrigan, A. May, P. L. Opresko, L. Dawut, W.-H. Cheng, and V. A. Bohr Central Role for the Werner Syndrome Protein/Poly(ADP-Ribose) Polymerase 1 Complex in the Poly(ADP-Ribosyl)ation Pathway after DNA Damage Mol. Cell. Biol., December 1, 2003; 23(23): 8601 - 8613. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Marsin, A. E. Vidal, M. Sossou, J. M.-d. Murcia, F. Le Page, S. Boiteux, G. de Murcia, and J. P. Radicella Role of XRCC1 in the Coordination and Stimulation of Oxidative DNA Damage Repair Initiated by the DNA Glycosylase hOGG1 J. Biol. Chem., November 7, 2003; 278(45): 44068 - 44074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. El-Khamisy, M. Masutani, H. Suzuki, and K. W. Caldecott A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage Nucleic Acids Res., October 1, 2003; 31(19): 5526 - 5533. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Flohr, A. Burkle, J. P. Radicella, and B. Epe Poly(ADP-ribosyl)ation accelerates DNA repair in a pathway dependent on Cockayne syndrome B protein Nucleic Acids Res., September 15, 2003; 31(18): 5332 - 5337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Veuger, N. J. Curtin, C. J. Richardson, G. C. M. Smith, and B. W. Durkacz Radiosensitization and DNA Repair Inhibition by the Combined Use of Novel Inhibitors of DNA-dependent Protein Kinase and Poly(ADP-Ribose) Polymerase-1 Cancer Res., September 15, 2003; 63(18): 6008 - 6015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Nakamura, S. Asakura, S. D. Hester, G. de Murcia, K. W. Caldecott, and J. A. Swenberg Quantitation of intracellular NAD(P)H can monitor an imbalance of DNA single strand break repair in base excision repair deficient cells in real time Nucleic Acids Res., September 1, 2003; 31(17): e104 - e104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Tartier, C. Spenlehauer, H. C. Newman, M. Folkard, K. M. Prise, B. D. Michael, J. Menissier-de Murcia, and G. de Murcia Local DNA damage by proton microbeam irradiation induces poly(ADP-ribose) synthesis in mammalian cells Mutagenesis, September 1, 2003; 18(5): 411 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Leppard, Z. Dong, Z. B. Mackey, and A. E. Tomkinson Physical and Functional Interaction between DNA Ligase III{alpha} and Poly(ADP-Ribose) Polymerase 1 in DNA Single-Strand Break Repair Mol. Cell. Biol., August 15, 2003; 23(16): 5919 - 5927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Okano, L. Lan, K. W. Caldecott, T. Mori, and A. Yasui Spatial and Temporal Cellular Responses to Single-Strand Breaks in Human Cells Mol. Cell. Biol., June 1, 2003; 23(11): 3974 - 3981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Le Page, V. Schreiber, C. Dherin, G. de Murcia, and S. Boiteux Poly(ADP-ribose) Polymerase-1 (PARP-1) Is Required in Murine Cell Lines for Base Excision Repair of Oxidative DNA Damage in the Absence of DNA Polymerase beta J. Biol. Chem., May 9, 2003; 278(20): 18471 - 18477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lebel, J. Lavoie, I. Gaudreault, M. Bronsard, and R. Drouin Genetic Cooperation between the Werner Syndrome Protein and Poly(ADP-Ribose) Polymerase-1 in Preventing Chromatid Breaks, Complex Chromosomal Rearrangements, and Cancer in Mice Am. J. Pathol., May 1, 2003; 162(5): 1559 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Augustin, C. Spenlehauer, H. Dumond, J. Menissier-de Murcia, M. Piel, A.-C. Schmit, F. Apiou, J.-L. Vonesch, M. Kock, M. Bornens, et al. PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression J. Cell Sci., April 15, 2003; 116(8): 1551 - 1562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Miknyoczki, S. Jones-Bolin, S. Pritchard, K. Hunter, H. Zhao, W. Wan, M. Ator, R. Bihovsky, R. Hudkins, S. Chatterjee, et al. Chemopotentiation of Temozolomide, Irinotecan, and Cisplatin Activity by CEP-6800, a Poly(ADP-Ribose) Polymerase Inhibitor Mol. Cancer Ther., April 1, 2003; 2(4): 371 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Masutani and M. Miwa Poly(ADP-ribose) Polymerase and Cancer: In Relation to the Lectures Presented by Dr Gilbert de Murcia Jpn. J. Clin. Oncol., November 1, 2002; 32(11): 483 - 487. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
