| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print July 11, 2002
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Toyama 930-0194
Corresponding Author: tsuda{at}ms.toyama-mpu.ac.jp
The use of different brain-derived neurotrophic factor (BDNF) gene promoters results in the differential production of 5Õ-alternative transcripts, suggesting versatile functions of BDNF in neurons. Among four BDNF promoters I, II, III and IV (BDNF-PI, -PII, -PIII and -PIV), BDNF-PI was markedly activated, as well as BDNF-PIII, by Ca2+ signals evoked via neuronal activity. However, little is known about the mechanisms for the transcriptional activation of BDNF-PI. Using rat cortical neurons in culture, we assigned the promoter sequences responsible for the Ca2+ signal-mediated activation of BDNF-PI, and found that the Ca2+ responsive elements were located in two separate (distal and proximal) regions and that the DNA sequences in the proximal region, containing cAMP-responsive element (CRE) which is overlapped by the upstream stimulatory factor (USF)-binding element, were largely responsible for the activation of BDNF-PI. CRE-binding protein (CREB) family transcription factors and USF1/USF2 bind to this overlapping site, depending upon their prefered sequences which also control the magnitude of the activation. Over-expression of dominant negative CREB or USF reduced the BDNF-PI activation. These findings support that not only CREB but also USF1/USF2 contributes to Ca2+ signal-mediated activation of BDNF-PI through the recognition of an overlaping CRE and USF-binding element.
J. Biol. Chem, 10.1074/jbc.M204784200
Submitted on May 16, 2002
Revised on July 1, 2002
Accepted on July 11, 2002
Involvement of an upstream stimulatory factor as well as cAMP responsive element-binding protein in the activation of brain-derived neurotrophic factor gene promoter I
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T.-C. Lu, Z. Wang, X. Feng, P. Chuang, W. Fang, Y. Chen, S. Neves, A. Maayan, H. Xiong, Y. Liu, et al. Retinoic Acid Utilizes CREB and USF1 in a Transcriptional Feed-Forward Loop in Order To Stimulate MKP1 Expression in Human Immunodeficiency Virus-Infected Podocytes Mol. Cell. Biol., September 15, 2008; 28(18): 5785 - 5794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Ciccone, C. T. Lacza, M. Y. Hou, S. J. Gregory, K.-Y. Kam, S. Xu, and U. B. Kaiser A Composite Element that Binds Basic Helix Loop Helix and Basic Leucine Zipper Transcription Factors Is Important for Gonadotropin-Releasing Hormone Regulation of the Follicle-Stimulating Hormone {beta} Gene Mol. Endocrinol., August 1, 2008; 22(8): 1908 - 1923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Mellstrom, M. Savignac, R. Gomez-Villafuertes, and J. R. Naranjo Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models Physiol Rev, April 1, 2008; 88(2): 421 - 449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Singer, R. Panford-Walsh, D. Watermann, O. Hendrich, U. Zimmermann, I. Kopschall, K. Rohbock, and M. Knipper Salicylate Alters the Expression of Calcium Response Transcription Factor 1 in the Cochlea: Implications for Brain-Derived Neurotrophic Factor Transcriptional Regulation Mol. Pharmacol., April 1, 2008; 73(4): 1085 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. El-Haroun, D. L. Clarke, K. Deacon, D. Bradbury, A. Clayton, A. Sutcliffe, and A. J. Knox IL-1{beta}, BK, and TGF-{beta}1 attenuate PGI2-mediated cAMP formation in human pulmonary artery smooth muscle cells by multiple mechanisms involving p38 MAP kinase and PKA Am J Physiol Lung Cell Mol Physiol, March 1, 2008; 294(3): L553 - L562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-C. Ou and P.-W. Gean Transcriptional Regulation of Brain-Derived Neurotrophic Factor in the Amygdala during Consolidation of Fear Memory Mol. Pharmacol., August 1, 2007; 72(2): 350 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ohmae, S. Takemoto-Kimura, M. Okamura, A. Adachi-Morishima, M. Nonaka, T. Fuse, S. Kida, M. Tanji, T. Furuyashiki, Y. Arakawa, et al. Molecular Identification and Characterization of a Family of Kinases with Homology to Ca2+/Calmodulin-dependent Protein Kinases I/IV J. Biol. Chem., July 21, 2006; 281(29): 20427 - 20439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Shibata, T. Ohnuma, S. Higashi, M. Higashi, C. Usui, T. Ohkubo, T. Watanabe, R. Kawashima, A. Kitajima, A. Ueki, et al. Genetic Association Between USF 1 and USF 2 Gene Polymorphisms and Japanese Alzheimer's Disease. J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2006; 61(7): 660 - 662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Mousavi and B. J. Jasmin BDNF Is Expressed in Skeletal Muscle Satellite Cells and Inhibits Myogenic Differentiation J. Neurosci., May 24, 2006; 26(21): 5739 - 5749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Guindalini, M. Howard, K. Haddley, R. Laranjeira, D. Collier, N. Ammar, I. Craig, C. O'Gara, V. J. Bubb, T. Greenwood, et al. A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample PNAS, March 21, 2006; 103(12): 4552 - 4557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fukuchi, A. Tabuchi, and M. Tsuda Activity-dependent Transcriptional Activation and mRNA Stabilization for Cumulative Expression of Pituitary Adenylate Cyclase-activating Polypeptide mRNA Controlled by Calcium and cAMP Signals in Neurons J. Biol. Chem., November 12, 2004; 279(46): 47856 - 47865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Rattiner, M. Davis, and K. J. Ressler Differential regulation of brain-derived neurotrophic factor transcripts during the consolidation of fear learning Learn. Mem., November 1, 2004; 11(6): 727 - 731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Steiger, S. Bandyopadhyay, D. H. Farb, and S. J. Russek cAMP Response Element-Binding Protein, Activating Transcription Factor-4, and Upstream Stimulatory Factor Differentially Control Hippocampal GABABR1a and GABABR1b Subunit Gene Expression through Alternative Promoters J. Neurosci., July 7, 2004; 24(27): 6115 - 6126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Charney and H. K. Manji Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention Sci. Signal., March 23, 2004; 2004(225): re5 - re5. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sayasith, N. Bouchard, M. Sawadogo, J. G. Lussier, and J. Sirois Molecular Characterization and Role of Bovine Upstream Stimulatory Factor 1 and 2 in the Regulation of the Prostaglandin G/H Synthase-2 Promoter in Granulosa Cells J. Biol. Chem., February 20, 2004; 279(8): 6327 - 6336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. E. Huber, E. R. Price, H. R. Widlund, J. Du, I. J. Davis, M. Wegner, and D. E. Fisher A Tissue-restricted cAMP Transcriptional Response: SOX10 MODULATES {alpha}-MELANOCYTE-STIMULATING HORMONE-TRIGGERED EXPRESSION OF MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR IN MELANOCYTES J. Biol. Chem., November 14, 2003; 278(46): 45224 - 45230. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Kingsbury, P. D. Murray, L. L. Bambrick, and B. K. Krueger Ca2+-dependent Regulation of TrkB Expression in Neurons J. Biol. Chem., October 17, 2003; 278(42): 40744 - 40748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fang, J. Chartier, C. Sodja, A. Desbois, M. Ribecco-Lutkiewicz, P. R. Walker, and M. Sikorska Transcriptional Activation of the Human Brain-derived Neurotrophic Factor Gene Promoter III by Dopamine Signaling in NT2/N Neurons J. Biol. Chem., July 11, 2003; 278(29): 26401 - 26409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. G. Chen, A. E. West, X. Tao, G. Corfas, M. N. Szentirmay, M. Sawadogo, C. Vinson, and M. E. Greenberg Upstream Stimulatory Factors Are Mediators of Ca2+-Responsive Transcription in Neurons J. Neurosci., April 1, 2003; 23(7): 2572 - 2581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Durham and A. F. Russo Stimulation of the Calcitonin Gene-Related Peptide Enhancer by Mitogen-Activated Protein Kinases and Repression by an Antimigraine Drug in Trigeminal Ganglia Neurons J. Neurosci., February 1, 2003; 23(3): 807 - 815. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
