| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print July 2, 2002
Nutritional Sciences, University of Missouri-Columbia, Columbia, MO 65211
Corresponding Author: eided{at}missouri.edu
Acquisition of metals such as Fe, Cu, and Zn by the yeast Saccharomyces cerevisiae is tightly regulated. High affinity uptake systems are induced under metal-limiting conditions to maintain an adequate supply of these essential nutrients. Low affinity uptake systems function when their substrates are in greater supply. The FET4 gene encodes a low affinity Fe and Cu uptake transporter. FET4 expression is regulated by several environmental factors. In this report, we describe the molecular mechanisms underlying this regulation. First, we found that FET4 expression is induced in Fe-limited cells by the Aft1 Fe-responsive transcriptional activator. Second, FET4 is regulated by Zn status via the Zap1 transcription factor. We present evidence that FET4 is a physiologically relevant Zn transporter and this provides a rationale for its regulation by Zap1. Finally, FET4 expression is regulated in response to oxygen by the Rox1 repressor. Rox1 attenuates activation by Aft1 and Zap1 in aerobic cells. Derepression of FET4 may allow the Fet4 transporter to play an even greater role in metal acquisition under anaerobic conditions. Thus, Fet4 is a multi-substrate metal ion transporter under combinatorial control by Fe, Zn and oxygen.
J. Biol. Chem, 10.1074/jbc.M206214200
Submitted on June 21, 2002
Revised on June 28, 2002
Accepted on July 2, 2002
Combinatorial control of yeast FET4 gene expression by iron, zinc, and oxygen
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Pedas, C. K. Ytting, A. T. Fuglsang, T. P. Jahn, J. K. Schjoerring, and S. Husted Manganese Efficiency in Barley: Identification and Characterization of the Metal Ion Transporter HvIRT1 Plant Physiology, September 1, 2008; 148(1): 455 - 466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Soto and G. M. Carman Regulation of the Saccharomyces cerevisiae CKI1-encoded Choline Kinase by Zinc Depletion J. Biol. Chem., April 11, 2008; 283(15): 10079 - 10088. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Dainty, C. A. Kennedy, S. Watt, J. Bahler, and S. K. Whitehall Response of Schizosaccharomyces pombe to Zinc Deficiency Eukaryot. Cell, March 1, 2008; 7(3): 454 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. De Nicola, L. A. Hazelwood, E. A. F. De Hulster, M. C. Walsh, T. A. Knijnenburg, M. J. T. Reinders, G. M. Walker, J. T. Pronk, J.-M. Daran, and P. Daran-Lapujade Physiological and Transcriptional Responses of Saccharomyces cerevisiae to Zinc Limitation in Chemostat Cultures Appl. Envir. Microbiol., December 1, 2007; 73(23): 7680 - 7692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miethke and M. A. Marahiel Siderophore-Based Iron Acquisition and Pathogen Control Microbiol. Mol. Biol. Rev., September 1, 2007; 71(3): 413 - 451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Simm, B. Lahner, D. Salt, A. LeFurgey, P. Ingram, B. Yandell, and D. J. Eide Saccharomyces cerevisiae Vacuole in Zinc Storage and Intracellular Zinc Distribution Eukaryot. Cell, July 1, 2007; 6(7): 1166 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Y. Wu, A. J. Bird, D. R. Winge, and D. J. Eide Regulation of the Yeast TSA1 Peroxiredoxin by ZAP1 Is an Adaptive Response to the Oxidative Stress of Zinc Deficiency J. Biol. Chem., January 26, 2007; 282(4): 2184 - 2195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lucena, B. M. Waters, F. J. Romera, M. J. Garcia, M. Morales, E. Alcantara, and R. Perez-Vicente Ethylene could influence ferric reductase, iron transporter, and H+-ATPase gene expression by affecting FER (or FER-like) gene activity J. Exp. Bot., December 1, 2006; 57(15): 4145 - 4154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. Kersting and G. M. Carman Regulation of the Saccharomyces cerevisiae EKI1-encoded Ethanolamine Kinase by Zinc Depletion J. Biol. Chem., May 12, 2006; 281(19): 13110 - 13116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Han, G.-S. Han, W. M. Iwanyshyn, and G. M. Carman Regulation of the PIS1-encoded Phosphatidylinositol Synthase in Saccharomyces cerevisiae by Zinc J. Biol. Chem., August 12, 2005; 280(32): 29017 - 29024. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. Ellis, C. W. MacDiarmid, and D. J. Eide Heteromeric Protein Complexes Mediate Zinc Transport into the Secretory Pathway of Eukaryotic Cells J. Biol. Chem., August 5, 2005; 280(31): 28811 - 28818. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-C. Lai, A. L. Kosorukoff, P. V. Burke, and K. E. Kwast Dynamical Remodeling of the Transcriptome during Short-Term Anaerobiosis in Saccharomyces cerevisiae: Differential Response and Role of Msn2 and/or Msn4 and Other Factors in Galactose and Glucose Media Mol. Cell. Biol., May 15, 2005; 25(10): 4075 - 4091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Ellis, F. Wang, C. W. MacDiarmid, S. Clark, T. Lyons, and D. J. Eide Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function J. Cell Biol., August 2, 2004; 166(3): 325 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Iwanyshyn, G.-S. Han, and G. M. Carman Regulation of Phospholipid Synthesis in Saccharomyces cerevisiae by Zinc J. Biol. Chem., May 21, 2004; 279(21): 21976 - 21983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Serrano, D. Bernal, E. Simon, and J. Arino Copper and Iron Are the Limiting Factors for Growth of the Yeast Saccharomyces cerevisiae in an Alkaline Environment J. Biol. Chem., May 7, 2004; 279(19): 19698 - 19704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. De Freitas, J. H. Kim, H. Poynton, T. Su, H. Wintz, T. Fox, P. Holman, A. Loguinov, S. Keles, M. van der Laan, et al. Exploratory and Confirmatory Gene Expression Profiling of mac1{Delta} J. Biol. Chem., February 6, 2004; 279(6): 4450 - 4458. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. C. Rutherford and A. J. Bird Metal-Responsive Transcription Factors That Regulate Iron, Zinc, and Copper Homeostasis in Eukaryotic Cells Eukaryot. Cell, February 1, 2004; 3(1): 1 - 13. [Full Text] [PDF]
|
|
|
|
|
|
R. J. Crisp, A. Pollington, C. Galea, S. Jaron, Y. Yamaguchi-Iwai, and J. Kaplan Inhibition of Heme Biosynthesis Prevents Transcription of Iron Uptake Genes in Yeast J. Biol. Chem., November 14, 2003; 278(46): 45499 - 45506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J. Eide Multiple Regulatory Mechanisms Maintain Zinc Homeostasis in Saccharomyces cerevisiae J. Nutr., May 1, 2003; 133(5): 1532S - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. MacDiarmid, M. A. Milanick, and D. J. Eide Induction of the ZRC1 Metal Tolerance Gene in Zinc-limited Yeast Confers Resistance to Zinc Shock J. Biol. Chem., April 18, 2003; 278(17): 15065 - 15072. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
