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A more recent version of this article appeared on November 22, 2002
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277/48/46273    most recent
M206274200v1
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Papers In Press, published online ahead of print September 6, 2002
J. Biol. Chem, 10.1074/jbc.M206274200
Submitted on June 24, 2002
Revised on August 22, 2002
Accepted on September 6, 2002

Dynamics-modulated biological activity of transforming growth factor beta 3

Eduard V. Bocharov, Dmitry M. Korzhnev, Marcel J. Blommers, Tudor Arvinte, Vladislav Y. Orekhov, Martin Billeter, and Alexander S. Arseniev

Core Technologies, Novartis Pharma AG, Basel CH-4002

Corresponding Author: marcel_jj.blommers{at}pharma.novartis.com

Transforming growth factor beta 3 (TGF-beta 3) is an important mediator of growth, maintenance and repair processes in human cells. Internal dynamic properties have been derived from 15N NMR relaxation data and mapped onto the spatial structure of TGF-beta 3. The pattern of internal dynamics in the structure identifies potential ‘hot spots’ of binding free energy and reveals the importance of conformational entropy in the interaction of TGF-beta 3 with the receptors. The observed internal dynamics sets TGF-beta 3 apart from other TGF-beta isoforms, with which it shares the same fold. These findings explain functional differences among the various TGF-beta isoforms and thus prove essential in the search for related therapeutic agents.


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