| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print September 25, 2002
J. Biol. Chem, 10.1074/jbc.M207623200
Submitted on July 29, 2002
Revised on September 17, 2002
Accepted on September 25, 2002
Pathology, University of Southern California, Los Angeles, CA 90089-9092
Corresponding Author: stallcup{at}usc.edu
The p160 coactivator complex plays a critical role in transcriptional activation by nuclear receptors and possibly other classes of DNA-binding transcriptional activators. The complex contains at least one of the three p160 coactivators (SRC-1, GRIP1/TIF2, or pCIP/RAC3/ACTR/AIB1/TRAM1), a histone acetyltransferase such as CBP or p300, and the histone methyltransferase CARM1 (coactivator associated arginine methyltransferase 1). Methylation of histone H3 and possibly other proteins in the transcription initiation complex by CARM1 occurs along with acetylation of histones and other proteins by CBP and p300 to help remodel chromatin structure and recruit RNA polymerase II. Here we show that other domains of CARM1 are required for the coactivator function of CARM1 in addition to the methyltransferase activity. The methyltransferase, GRIP1 binding, and homo-oligomerization activities all reside in the central region of CARM1, which is highly conserved among the entire protein arginine methyltransferase family. In addition to this conserved domain, the unique N-terminal and C-terminal regions of CARM1 were also required for enhancement of transcriptional activation by nuclear receptors. While the N-terminal region has no known activity at present, the C-terminal part of CARM1 contains an autonomous activation domain, suggesting that it interacts with other proteins that help to mediate CARM1 coactivator function.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Frietze, M. Lupien, P. A. Silver, and M. Brown CARM1 Regulates Estrogen-Stimulated Breast Cancer Growth through Up-regulation of E2F1 Cancer Res., January 1, 2008; 68(1): 301 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Y. Lee, I. Ianculescu, D. Purcell, X. Zhang, X. Cheng, and M. R. Stallcup Surface-Scanning Mutational Analysis of Protein Arginine Methyltransferase 1: Roles of Specific Amino Acids in Methyltransferase Substrate Specificity, Oligomerization, and Coactivator Function Mol. Endocrinol., June 1, 2007; 21(6): 1381 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsuda, B. D. Paul, C. Y. Choi, and Y.-B. Shi Contrasting Effects of Two Alternative Splicing Forms of Coactivator-Associated Arginine Methyltransferase 1 on Thyroid Hormone Receptor-Mediated Transcription in Xenopus laevis Mol. Endocrinol., May 1, 2007; 21(5): 1082 - 1094. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Passeri, A. Marcucci, G. Rizzo, M. Billi, M. Panigada, L. Leonardi, F. Tirone, and F. Grignani Btg2 enhances retinoic Acid-induced differentiation by modulating histone h4 methylation and acetylation. Mol. Cell. Biol., July 1, 2006; 26(13): 5023 - 5032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Teyssier, C.-Y. Ou, K. Khetchoumian, R. Losson, and M. R. Stallcup Transcriptional Intermediary Factor 1{alpha} Mediates Physical Interaction and Functional Synergy between the Coactivator-Associated Arginine Methyltransferase 1 and Glucocorticoid Receptor-Interacting Protein 1 Nuclear Receptor Coactivators Mol. Endocrinol., June 1, 2006; 20(6): 1276 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Kim, C. K. Yang, and M. R. Stallcup Downstream signaling mechanism of the C-terminal activation domain of transcriptional coactivator CoCoA. Nucleic Acids Res., January 1, 2006; 34(9): 2736 - 2750. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Zhou, J. Yan, W. Luo, G. Ayala, S.-H. Lin, H. Erdem, M. Ittmann, S. Y. Tsai, and M.-J. Tsai SRC-3 Is Required for Prostate Cancer Cell Proliferation and Survival Cancer Res., September 1, 2005; 65(17): 7976 - 7983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ohkura, M. Takahashi, H. Yaguchi, Y. Nagamura, and T. Tsukada Coactivator-associated Arginine Methyltransferase 1, CARM1, Affects Pre-mRNA Splicing in an Isoform-specific Manner J. Biol. Chem., August 12, 2005; 280(32): 28927 - 28935. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Y. Lee, C. Teyssier, B. D. Strahl, and M. R. Stallcup Role of Protein Methylation in Regulation of Transcription Endocr. Rev., April 1, 2005; 26(2): 147 - 170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ananthanarayanan, S. Li, N. Balasubramaniyan, F. J. Suchy, and M. J. Walsh Ligand-dependent Activation of the Farnesoid X-receptor Directs Arginine Methylation of Histone H3 by CARM1 J. Biol. Chem., December 24, 2004; 279(52): 54348 - 54357. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hoang, I. S. Fenne, C. Cook, B. Borud, M. Bakke, E. A. Lien, and G. Mellgren cAMP-dependent Protein Kinase Regulates Ubiquitin-Proteasome-mediated Degradation and Subcellular Localization of the Nuclear Receptor Coactivator GRIP1 J. Biol. Chem., November 19, 2004; 279(47): 49120 - 49130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C M Klinge, S C Jernigan, K A Mattingly, K E Risinger, and J Zhang Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors {alpha} and {beta} by coactivators and corepressors J. Mol. Endocrinol., October 1, 2004; 33(2): 387 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Cakouros, T. J. Daish, K. Mills, and S. Kumar An Arginine-Histone Methyltransferase, CARMER, Coordinates Ecdysone-mediated Apoptosis in Drosophila Cells J. Biol. Chem., April 30, 2004; 279(18): 18467 - 18471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-H. Lee, H. D. Campbell, and M. R. Stallcup Developmentally Essential Protein Flightless I Is a Nuclear Receptor Coactivator with Actin Binding Activity Mol. Cell. Biol., March 1, 2004; 24(5): 2103 - 2117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Li, J. H. Kim, S. S. Koh, and M. R. Stallcup Synergistic Effects of Coactivators GRIP1 and {beta}-Catenin on Gene Activation: CROSS-TALK BETWEEN ANDROGEN RECEPTOR AND Wnt SIGNALING PATHWAYS J. Biol. Chem., February 6, 2004; 279(6): 4212 - 4220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Monroy, N. M. Schott, L. Cox, J. D. Chen, M. Ruh, and J. C. Chrivia SNF2-Related CBP Activator Protein (SRCAP) Functions as a Coactivator of Steroid Receptor-Mediated Transcription through Synergistic Interactions with CARM-1 and GRIP-1 Mol. Endocrinol., December 1, 2003; 17(12): 2519 - 2528. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
