| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print December 9, 2002
Radiation Oncology, Loyola University Medical Center, Maywood,, IL 60153
Corresponding Author: gchen1{at}lumc.edu
p38 MAPK pathway signaling is known to participate in cell proliferation, apoptosis, and differentiation, in a manner dependent on the cellular context. The factors that determine the specific biological response in a given cell-type however remain largely unknown. We report opposite effects of the p38 isoforms on regulation of AP-1–dependent activities by p38 activators MKK6 and/or arsenite (ARS) in human breast cancer cells. The p38b isoform increases the activation of AP-1 transcriptional activities by MKK6 and/or ARS, whereas p38g/p38d inhibits or has no effect on the stimulation. The p38b does so by increasing the levels of phosphorylated c-Jun, while the p38g and d isoforms may act by regulating the c-Jun transcription. AP-1 dependent process such as vitamin D receptor (VDR) gene promoter activation and cellular proliferation were similarly activated by the p38b or inhibited by the p38g and/or d isoforms. While the human breast cancer cells express all four isoforms, mouse NIH 3T3 and EMT-6 cells express only some of the p38 family members, with p38b higher in 3T3 cells but p38d only detected in EMT-6 line. Consistent with the positive and negative roles of p38b and p38d in AP-1 regulation, MKK6 stimulates AP-1-dependent transcription in NIH 3T3 but not EMT-6 cells. In support of a role of c-Jun regulation by p38 isoforms in determining AP-1 activity, the levels of endogenous c-Jun and its phosphorylated form on p38 activation are higher in NIH 3T3 cells. These results demonstrate the contrasting activities of the different p38 isoforms in transmitting the upstream signal to AP-1 and show that the expression profile of p38 isoforms determines whether the p38 signal pathway activates or inhibits AP-1-dependent processes.
J. Biol. Chem, 10.1074/jbc.M207732200
Submitted on July 31, 2002
Revised on December 9, 2002
Accepted on December 9, 2002
p38 isoforms have opposite effects on AP-1-dependent transcription through regulation of c-Jun: The determinant role of the isoforms in the p38 MAPK signal specificity
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Gutierrez-Sanmartin, E. Varela-Ledo, A. Aguilera, S. Romero-Yuste, P. Romero-Jung, A. Gomez-Tato, and B. J. Regueiro Implication of p38 mitogen-activated protein kinase isoforms ({alpha}, {beta}, {gamma} and {delta}) in CD4+ T-cell infection with human immunodeficiency virus type I J. Gen. Virol., July 1, 2008; 89(7): 1661 - 1671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Abidi, H. Zhang, S. M Zaidi, W.-J. Shen, S. Leers-Sucheta, Y. Cortez, J. Han, and S. Azhar Oxidative stress-induced inhibition of adrenal steroidogenesis requires participation of p38 mitogen-activated protein kinase signaling pathway J. Endocrinol., July 1, 2008; 198(1): 193 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Sebe, S.-K. Leivonen, A. Fintha, A. Masszi, L. Rosivall, V.-M. Kahari, and I. Mucsi Transforming growth factor-{beta}-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38{beta} mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling during epithelial-myofibroblast transdifferentiation Nephrol. Dial. Transplant., May 1, 2008; 23(5): 1537 - 1545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Martin, L. A. Allan, E. J. Mancini, and P. R. Clarke The Docking Interaction of Caspase-9 with ERK2 Provides a Mechanism for the Selective Inhibitory Phosphorylation of Caspase-9 at Threonine 125 J. Biol. Chem., February 15, 2008; 283(7): 3854 - 3865. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Qi, N. M. Pohl, M. Loesch, S. Hou, R. Li, J.-Z. Qin, A. Cuenda, and G. Chen p38{alpha} Antagonizes p38{gamma} Activity through c-Jun-dependent Ubiquitin-proteasome Pathways in Regulating Ras Transformation and Stress Response J. Biol. Chem., October 26, 2007; 282(43): 31398 - 31408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Kelley, A. Rose, K. Song, B. Lystrup, J. W. Samples, and T. S. Acott p38 MAP Kinase Pathway and Stromelysin Regulation in Trabecular Meshwork Cells Invest. Ophthalmol. Vis. Sci., July 1, 2007; 48(7): 3126 - 3137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Askari, R. Diskin, M. Avitzour, R. Capone, O. Livnah, and D. Engelberg Hyperactive Variants of p38{alpha} Induce, whereas Hyperactive Variants of p38{gamma} Suppress, Activating Protein 1-mediated Transcription J. Biol. Chem., January 5, 2007; 282(1): 91 - 99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-S. Keum, S. Yu, P. P.-J. Chang, X. Yuan, J.-H. Kim, C. Xu, J. Han, A. Agarwal, and A.-N. T. Kong Mechanism of Action of Sulforaphane: Inhibition of p38 Mitogen-Activated Protein Kinase Isoforms Contributing to the Induction of Antioxidant Response Element-Mediated Heme Oxygenase-1 in Human Hepatoma HepG2 Cells. Cancer Res., September 1, 2006; 66(17): 8804 - 8813. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Qi, J. Tang, M. Loesch, N. Pohl, S. Alkan, and G. Chen p38{gamma} Mitogen-Activated Protein Kinase Integrates Signaling Crosstalk between Ras and Estrogen Receptor to Increase Breast Cancer Invasion. Cancer Res., August 1, 2006; 66(15): 7540 - 7547. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ambrose, A. Ryan, G. C. O'Sullivan, C. Dunne, and O. P. Barry Induction of Apoptosis in Renal Cell Carcinoma by Reactive Oxygen Species: Involvement of Extracellular Signal-Regulated Kinase 1/2, p38{delta}/{gamma}, Cyclooxygenase-2 Down-Regulation, and Translocation of Apoptosis-Inducing Factor Mol. Pharmacol., June 1, 2006; 69(6): 1879 - 1890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. N'Guessan, S. Hippenstiel, M. O. Etouem, J. Zahlten, W. Beermann, D. Lindner, B. Opitz, M. Witzenrath, S. Rosseau, N. Suttorp, et al. Streptococcus pneumoniae induced p38 MAPK- and NF-{kappa}B-dependent COX-2 expression in human lung epithelium Am J Physiol Lung Cell Mol Physiol, June 1, 2006; 290(6): L1131 - L1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Proia, B. W. Nannenga, L. A. Donehower, and N. L. Weigel Dual Roles for the Phosphatase PPM1D in Regulating Progesterone Receptor Function J. Biol. Chem., March 17, 2006; 281(11): 7089 - 7101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Krull, P. Bockstaller, F. N. Wuppermann, A. C. Klucken, J. Muhling, B. Schmeck, J. Seybold, C. Walter, M. Maass, S. Rosseau, et al. Mechanisms of Chlamydophila pneumoniae-Mediated GM-CSF Release in Human Bronchial Epithelial Cells Am. J. Respir. Cell Mol. Biol., March 1, 2006; 34(3): 375 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Meng, Y. Yamagiwa, S. Taffetani, J. Han, and T. Patel IL-6 activates serum and glucocorticoid kinase via p38{alpha} mitogen-activated protein kinase pathway Am J Physiol Cell Physiol, October 1, 2005; 289(4): C971 - C981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Tang, X. Qi, D. Mercola, J. Han, and G. Chen Essential Role of p38{gamma} in K-Ras Transformation Independent of Phosphorylation J. Biol. Chem., June 24, 2005; 280(25): 23910 - 23917. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. McMullen, P. W. Bryant, C. C. Glembotski, P. A. Vincent, and K. M. Pumiglia Activation of p38 Has Opposing Effects on the Proliferation and Migration of Endothelial Cells J. Biol. Chem., June 3, 2005; 280(22): 20995 - 21003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tanos, M. J. Marinissen, F. C. Leskow, D. Hochbaum, H. Martinetto, J. S. Gutkind, and O. A. Coso Phosphorylation of c-Fos by Members of the p38 MAPK Family: ROLE IN THE AP-1 RESPONSE TO UV LIGHT J. Biol. Chem., May 13, 2005; 280(19): 18842 - 18852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Schmeck, J. Zahlten, K. Moog, V. van Laak, S. Huber, A. C. Hocke, B. Opitz, E. Hoffmann, M. Kracht, J. Zerrahn, et al. Streptococcus pneumoniae-induced p38 MAPK-dependent Phosphorylation of RelA at the Interleukin-8 Promotor J. Biol. Chem., December 17, 2004; 279(51): 53241 - 53247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Gutzman, D. E. Rugowski, M. D. Schroeder, J. J. Watters, and L. A. Schuler Multiple Kinase Cascades Mediate Prolactin Signals to Activating Protein-1 in Breast Cancer Cells Mol. Endocrinol., December 1, 2004; 18(12): 3064 - 3075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Abecassis, E. Rogier, A. Vazquez, A. Atfi, and M.-F. Bourgeade Evidence for a Role of MSK1 in Transforming Growth Factor-{beta}-mediated Responses through p38{alpha} and Smad Signaling Pathways J. Biol. Chem., July 16, 2004; 279(29): 30474 - 30479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Man, S. Rustaeus, D. M. Price, C. L. Chik, and A. K. Ho Inhibition of p38 Mitogen-Activated Protein Kinase Enhances Adrenergic-Stimulated Arylalkylamine N-Acetyltransferase Activity in Rat Pinealocytes Endocrinology, March 1, 2004; 145(3): 1167 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Qi, S. Borowicz, R. Pramanik, R. M. Schultz, J. Han, and G. Chen Estrogen Receptor Inhibits c-Jun-dependent Stress-induced Cell Death by Binding and Modifying c-Jun Activity in Human Breast Cancer Cells J. Biol. Chem., February 20, 2004; 279(8): 6769 - 6777. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. E. Frigo, Y. Tang, B. S. Beckman, A. B. Scandurro, J. Alam, M. E. Burow, and J. A. McLachlan Mechanism of AP-1-mediated gene expression by select organochlorines through the p38 MAPK pathway Carcinogenesis, February 1, 2004; 25(2): 249 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Lui, C. Zeng, S. Acton, S. Cok, A. Sexton, and A. R. Morrison Effects of p38MAPK isoforms on renal mesangial cell inducible nitric oxide synthase expression Am J Physiol Cell Physiol, January 1, 2004; 286(1): C145 - C152. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hess, N. Wijayanti, A. P. Neuschafer-Rube, N. Katz, T. Kietzmann, and S. Immenschuh Phorbol Ester-dependent Activation of Peroxiredoxin I Gene Expression via a Protein Kinase C, Ras, p38 Mitogen-activated Protein Kinase Signaling Pathway J. Biol. Chem., November 14, 2003; 278(46): 45419 - 45434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Balasubramanian, R. K. Ganju, and J. E. Groopman Hepatitis C Virus and HIV Envelope Proteins Collaboratively Mediate Interleukin-8 Secretion through Activation of p38 MAP Kinase and SHP2 in Hepatocytes J. Biol. Chem., September 12, 2003; 278(37): 35755 - 35766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kietzmann, A. Samoylenko, and S. Immenschuh Transcriptional Regulation of Heme Oxygenase-1 Gene Expression by MAP Kinases of the JNK and p38 Pathways in Primary Cultures of Rat Hepatocytes J. Biol. Chem., May 9, 2003; 278(20): 17927 - 17936. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
