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Papers In Press, published online ahead of print May 5, 2003
Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0678
Corresponding Author: ghammer{at}umich.edu
The action of a variety of peptide hormones is critical for the proper growth and differentiation of the urogenital ridge, which ultimately gives rise to the kidney, adrenal cortex, and gonad. One such class of peptides is the Wnt family of secreted glycoproteins that is classically involved in development of cell polarity and cell fate determination. Notably, alterations in Wnt-4 expression in mice and humans result in profound defects in urogenital ridge development, including dysregulation of kidney, gonadal and adrenal growth. The nuclear receptor Steroidogenic Factor-1 (SF-1) has been implicated as a downstream effector of peptide hormone signaling during urogenital ridge development as evidenced by both the activation of SF-1 dependent transcription in the adrenal cortex by signaling molecules such as Protein Kinase A and by the adrenal and gonadal agenesis in mice with null mutations in SF-1. We hypothesized that Wnt-dependent signaling cascades regulate SF-1-dependent transcription of genes required for adrenogonadal development. Specifically, the data demonstrate that
J. Biol. Chem, 10.1074/jbc.M212677200
Submitted on December 12, 2002
Revised on April 8, 2003
Accepted on May 5, 2003
Convergence of Wnt signaling and SF-1 on transcription of the rat inhibin
gene
-catenin synergizes with SF-1 to activate the 
-inhibin promoter through formation of a transcriptional complex. The activation requires an intact SF-1 RE and is independent of TCF/Lef. These data support the recent observation that -catenin can participate in nuclear receptor mediated transcriptional activation and extend the findings to the monomer binding class of orphan nuclear receptors.
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