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M301685200v1
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Papers In Press, published online ahead of print March 27, 2003
J. Biol. Chem, 10.1074/jbc.M301685200
Submitted on February 18, 2003
Revised on March 25, 2003
Accepted on March 27, 2003

Telomerase expression in normal human fibroblasts stabilizes DNA 5-methylcytosine transferase I (DNMT1)

Juan I. Young, John M. Sedivy, and James R. Smith

Huffington Center on Aging, Baylor College of Medicine, Houston, TX 7030

Corresponding Author: jyoung{at}bcm.tmc.edu

The finite proliferative potential of normal human fibroblasts can be overcome, a process commonly called immortalization, by the introduction of the catalytic subunit of telomerase (hTERT). In contrast to malignant transformation, the pattern of gene expression remains largely unmodified in telomerase-induced immortalization. Here we show evidence that suggests that the maintenance of a "young" pattern of gene expression by telomerization is mediated, at least in part, by a novel function of hTERT that involves regulation of DNA methyltransferase I (DNMT1) gene expression


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