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Papers In Press, published online ahead of print September 17, 2004
Cancer Biology, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232
Corresponding Author: peng.liang{at}vanderbilt.edu
Although a number of target genes for the tumor suppressor p53 have been described, the mechanism of p53-dependent apoptosis is incompletely understood. Thus, it is essential to identify and characterize additional target genes that could mediate apoptosis. In the study reported here, we isolated a p53-regulated gene, named NDRG1. Its expression is induced by DNA damage in a p53-dependent fashion. The promoter region of NDRG1 gene contains a p53 binding site which confers p53-dependent transcriptional activation via a heterologous reporter. RNA interference and inducible gene expression approaches suggest that NDRG1 is necessary but not sufficient for p53-mediated caspase activation and apoptosis. This report further supports the notion that p53 controls a network of genes that are required for its apoptotic function.
J. Biol. Chem, 10.1074/jbc.M400386200
Submitted on January 14, 2004
Revised on August 20, 2004
Accepted on September 17, 2004
NDRG1 is necessary for p53-dependent apoptosis
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