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Papers In Press, published online ahead of print April 7, 2004
Department of Cell and Molecular Biology, Institution of Microbiology, Göteborg University, Göteborg 40530
Corresponding Author: Thomas.Nystrom{at}gmm.gu.se
Protein carbonylation is an irreversible oxidative process leading to a loss of function of the modified proteins and in a variety of model systems, including worms, flies, and mammals, carbonyl levels gradually increase with age. In contrast, we report here that in Arabidopsis thaliana an initial increase in protein oxidation during the first 20 days of the plant’s life cycle is followed by a drastic reduction in protein carbonyls prior to bolting and flower development. Protein carbonylation prior to the transition to flowering targets specific proteins such as Hsp70, ATP synthases, the large subunit of Rubisco, and proteins involved in light harvesting/energy transfer and the C2 oxidative photosynthetic carbon cycle. The precipitous fall in protein carbonyl levels is due to the specific reduction in the levels of oxidized proteins rather than an overall loss of chlorophyll and Rubisco associated with the senescence syndrome. The results are discussed in light of contemporary theories of aging in animals.
J. Biol. Chem, 10.1074/jbc.M402652200
Submitted on March 9, 2004
Revised on April 7, 2004
Accepted on April 7, 2004
Progression and specificity of protein oxidation in the life cycle of Arabidopsis thaliana
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