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A more recent version of this article appeared on October 1, 2004 Originally published In Press as doi:10.1074/jbc.M402744200 on August 11, 2004
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Papers In Press, published online ahead of print August 5, 2004
J. Biol. Chem, 10.1074/jbc.M402744200
Submitted on March 11, 2004
Revised on August 4, 2004
Accepted on August 5, 2004

Synchronized chemoenzymatic synthesis of monodisperse hyaluronan polymers

Wei Jing and Paul L. DeAngelis

Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104

Corresponding Author: paul-deangelis{at}ouhsc.edu

The length of the hyaluronan [HA] polysaccharide chain dictates its biological effects in many cellular and tissue systems. Long and short HA polymers often appear to have antagonistic or inverse effects. However, no source of very defined, uniform HA polymers with sizes greater than 10 kDa is currently available. We present a method to produce synthetic HA with very narrow size distributions in the range of ~16 kDa to ~2 MDa.


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