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A more recent version of this article appeared on September 3, 2004 Originally published In Press as doi:10.1074/jbc.M404594200 on July 6, 2004
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Papers In Press, published online ahead of print June 30, 2004
J. Biol. Chem, 10.1074/jbc.M404594200
Submitted on April 26, 2004
Revised on June 7, 2004
Accepted on June 30, 2004

Sok2p transcription factor is involved in adaptive program relevant for long-term survival of Saccharomyces cerevisiae colonies

Libuse Vachova, Frederic Devaux, Helena Kucerova, Marketa Ricicova, Claude Jacq, and Zdena Palkova

Department of Genetics and Microbiology, Charles University, Prague 2 12844

Corresponding Author: zdenap{at}natur.cuni.cz

Volatile ammonia functions as a long-range alarm signal important for the transition of yeast colonies to their adaptive alkali developmental phase and for their consequent long-term survival. Cells of aged Saccharomyces cerevisiae sok2 colonies deleted in the gene for Sok2p transcription factor are not able to release sufficient amount of ammonia out of the cells, they are more fragile than cells of wt colonies and they exhibit a survival defect. Genome-wide analysis on gene expression differences between sok2 and wt colonies revealed that sok2 colonies are not able to switch on the genes of adaptive metabolisms effectively and display unbalanced expression and activity of various enzymes involved in cell protection against oxidative damage. Impaired amino acid metabolism and insufficient activation of genes for putative ammonium exporters Ato and of those for some other membrane transporters may be responsible for observed defects in ammonia production. Thus, Sok2p appears to be important regulator of S. cerevisiae colony development. Gene expression differences caused by its absence in colonies differ from those previously described in liquid cultures, which suggests pleiotropic effect of Sok2p under different conditions.


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