JBC Anatrace, Inc.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on July 16, 2004
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
279/29/30844    most recent
M404651200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhao, Y.
Right arrow Articles by Chandraratna, R. A.S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhao, Y.
Right arrow Articles by Chandraratna, R. A.S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print May 6, 2004
J. Biol. Chem, 10.1074/jbc.M404651200
Submitted on April 27, 2004
Revised on May 5, 2004
Accepted on May 6, 2004

Casein kinase 1alpha interacts with retinoid X receptor and interferes with agonist-induced apoptosis

Yi Zhao, Suofu Qin, Larissa I. Atangan, Yanira Molina, Yumiko Okawa, Hieu T. Arpawong, Corine Ghosn, Jia-Hao Xiao, Vidyasagar Vuligonda, Geoffrey Brown, and Roshantha A.S. Chandraratna

Retinoid Reseach, Department of Biological Sciences, Allergan Inc., Irvine, CA 92612

Corresponding Author: zhao_yi{at}allergan.com

Agonists of retinoid X receptors (RXRs), that include the natural 9-cis retinoic acid and synthetic analogs, are potent inducers of growth arrest and apoptosis in some cancer cells. As such, they are being used in clinical trials for the treatment and prevention of solid tumors and are used to treat cutaneous T cell lymphoma. However, the molecular mechanisms that underlie the anti-cancer effects of RXR agonists remain unclear. Here, we show that a novel pro-apoptotic pathway that is induced by RXR agonist is negatively regulated by casein kinase 1 alpha (CK1alpha ). CK1alpha associates with RXR in an agonist-dependent manner and phosphorylates RXR. The ability of a RXR agonist to recruit CK1alpha to a complex with RXR in cells correlates inversely with its ability to inhibit growth. Remarkably, depletion of CK1alpha in resistant cells renders them susceptible to RXR agonist-induced growth inhibition and apoptosis. Our study shows that CK1alpha can promote cell survival by interfering with RXR agonist-induced apoptosis. Inhibition of CK1alpha may enhance the anti-cancer effects of RXR agonists.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. Xu, C. C. L. Wong, E. H. Y. Tong, S. S. M. Chung, J. R. Yates III, Y. Yin, and B. C. B. Ko
Phosphorylation by Casein Kinase 1 Regulates Tonicity-induced Osmotic Response Element-binding Protein/Tonicity Enhancer-binding Protein Nucleocytoplasmic Trafficking
J. Biol. Chem., June 20, 2008; 283(25): 17624 - 17634.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
H. Pang, A. Lin, M. Holford, B. E. Enerson, B. Lu, M. P. Lawton, E. Floyd, and H. Zhao
Pathway analysis using random forests classification and regression
Bioinformatics, August 15, 2006; 22(16): 2028 - 2036.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Kattapuram, S. Yang, J. L. Maki, and J. R. Stone
Protein Kinase CK1{alpha} Regulates mRNA Binding by Heterogeneous Nuclear Ribonucleoprotein C in Response to Physiologic Levels of Hydrogen Peroxide
J. Biol. Chem., April 15, 2005; 280(15): 15340 - 15347.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2004 by the American Society for Biochemistry and Molecular Biology.