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Papers In Press, published online ahead of print October 21, 2004
Division of Virology, Aichi Cancer Center Research Institute, Nagoya, Aichi 464-8681
Corresponding Author: ttsurumi{at}aichi-cc.jp
The Epstein-Barr virus nuclear antigen 1 (EBNA1) is required for maintenance of the viral genome DNA during latent phase of EBV replication, but continues to be synthesized after induction of viral productive replication. EBV genome-wide ChIP assay revealed that EBNA1 constantly binds to oriP of EBV genome during not only latent but also lytic infection. Although the total levels of the EBNA1 proved constant throughout the latter, the levels of oriP-bound form were increased as lytic infection proceeded. EBV productive DNA replication occurs at discrete sites in nuclei, called replication compartments, where viral replication proteins are clustered. Confocal laser microscopic analyses revealed that while EBNA1 was distributed broadly in nuclei as fine punctate dots during the latent phase of infection, the protein became redistributed to the viral replication compartments and localized as distinct spots within and/or nearby the compartments after induction of lytic replication. Taken into consideration, oriP regions of the EBV genome might be organized by EBNA1 into replication domains that might set up scaffolding for lytic replication and transcription.
J. Biol. Chem, 10.1074/jbc.M405911200
Submitted on May 27, 2004
Revised on September 7, 2004
Accepted on October 20, 2004
In vivo dynamics of EBNA1-OriP interaction during latent and lytic replication of Epstein-Barr virus
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