| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print March 1, 2005
Reproductive Medicine, University of California, San Diego, La Jolla, CA 92093-0674
Corresponding Author: pmellon{at}ucsd.edu
Gonadotropin-releasing hormone (GnRH) is the central regulator of the hypothalamic-pituitary-gonadal axis, controlling sexual maturation and fertility in diverse species from fish to humans. GnRH gene expression is limited to a discrete population of neurons that migrate through the nasal region into the hypothalamus during embryonic development. The GnRH regulatory region contains four conserved homeodomain binding sites (ATTA) that are essential for basal promoter activity and cell-specific expression of the GnRH gene. MSX and DLX are members of the Antennapedia class of non-Hox homeodomain transcription factors that regulate gene expression and influence development of the craniofacial structures and anterior forebrain. Here, we report that expression patterns of the Msx and Dlx families of homeodomain transcription factors largely coincide with the migratory route of GnRH neurons and co-express with GnRH in neurons during embryonic development. In addition, MSX and DLX family members bind directly to the ATTA consensus sequences and regulate transcriptional activity of the GnRH promoter. Finally, mice lacking MSX1 or DLX1 and 2 show altered numbers of GnRH-expressing cells in regions where these factors likely function. These findings strongly support a role for MSX and DLX in contributing to spatiotemporal regulation of GnRH transcription during development.
J. Biol. Chem, 10.1074/jbc.M502004200
Submitted on February 22, 2005
Revised on March 1, 2005
Accepted on March 1, 2005
Developmental regulation of gonadotropin-releasing hormone gene expression by the MSX and DLX homeodomain protein families
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  T. N. Le, G. Du, M. Fonseca, Q.-P. Zhou, J. T. Wigle, and D. D. Eisenstat Dlx Homeobox Genes Promote Cortical Interneuron Migration from the Basal Forebrain by Direct Repression of the Semaphorin Receptor Neuropilin-2 J. Biol. Chem., June 29, 2007; 282(26): 19071 - 19081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Chu and A. Ohtoshi Cloning and Functional Analysis of Hypothalamic Homeobox Gene Bsx1a and Its Isoform, Bsx1b Mol. Cell. Biol., May 15, 2007; 27(10): 3743 - 3749. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Diamond, M. Amen, Q. Hu, H. M. Espinoza, and B. A. Amendt Functional interactions between Dlx2 and lymphoid enhancer factor regulate Msx2 Nucleic Acids Res., November 6, 2006; 34(20): 5951 - 5965. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kuwajima, I. Nishimura, and K. Yoshikawa Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins. J. Neurosci., May 17, 2006; 26(20): 5383 - 5392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Tobet and G. A. Schwarting Minireview: Recent Progress in Gonadotropin-Releasing Hormone Neuronal Migration Endocrinology, March 1, 2006; 147(3): 1159 - 1165. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Tang, M. Mazur, and P. L. Mellon The Protein Kinase C Pathway Acts through Multiple Transcription Factors to Repress Gonadotropin-Releasing Hormone Gene Expression in Hypothalamic GT1-7 Neuronal Cells Mol. Endocrinol., November 1, 2005; 19(11): 2769 - 2779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Rave-Harel, N. L. G. Miller, M. L. Givens, and P. L. Mellon The Groucho-related Gene Family Regulates the Gonadotropin-releasing Hormone Gene through Interaction with the Homeodomain Proteins MSX1 and OCT1 J. Biol. Chem., September 2, 2005; 280(35): 30975 - 30983. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
