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Papers In Press, published online ahead of print May 6, 2005
J. Biol. Chem, 10.1074/jbc.M503925200
Submitted on April 11, 2005
Revised on May 5, 2005
Accepted on May 6, 2005

A cryptic rab1-binding site in the p115 tethering protein

Matthew Beard, Ayano Satoh, James Shorter, and Graham Warren

Cell Biology, Yale University, New Haven, CT 06520

Corresponding Author: graham.warren{at}yale.edu

Small GTPases and coiled-coil proteins of the golgin family help to tether COPI vesicles to Golgi membranes. At the cis-side of the Golgi, the Rab1 GTPase binds directly to each of three coiled-coil proteins: p115, GM130 and, as now shown, Giantin. Rab1 binds to a coiled-coil region within the tail domain of p115 and this binding is inhibited by the C-terminal, acidic domain of p115. Furthermore, GM130 and Giantin bind to the acidic domain of p115 and stimulate p115 binding to Rab1, suggesting that p115 binding to Rab1 is regulated. Regulation of this interaction by proteins such as GM130 and Giantin may control the membrane recruitment of p115 by Rab1.


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