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A more recent version of this article appeared on March 10, 2006
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M508982200v1
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Papers In Press, published online ahead of print January 5, 2006
J. Biol. Chem, 10.1074/jbc.M508982200
Submitted on August 15, 2005
Accepted on January 5, 2006

The down-regulation of HDACs during adipogenesis differentiation

Eung Jae Yoo, Jun-Jae Chung, Sung Sik Choe, Kang Ho Kim, and Jae Bum Kim

Department of Biological Sciences, Seoul National University, Seoul 151-742

Corresponding Author: jaebkim{at}snu.ac.kr

Specific cell type differentiation is driven by programmed regulation of gene expression which is the result of coordinated modulation of the transcription machinery and chromatin remodeling factors. We present evidence here that the down-regulation of histone deacetylases is an important process during adipocyte differentiation. In 3T3-L1 cells, histone hyperacetylation was selectively induced at the promoter regions of adipogenic genes during adipocyte differentiation. Interestingly, this was accompanied by a dramatic decrease in the expression level of several histone deacetylases including HDAC1, -2, and -5 and a reduction in overall histone deacetylase enzyme activity. Inhibition of histone deacetylase activity using sodium butyrate resulted in stimulation of adipogenic gene expression and adipocyte differentiation. Consistently, HDAC1 knock-down promoted adipogenesis while HDAC1 overexpression attenuated adipocyte differentiation in 3T3-L1 cells. Together, these results suggest that the regulation of not only adipogenic transcription factors, but also chromatin modifying enzymes is crucial for the execution of bona fide adipogenesis.


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