|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print January 17, 2006
Department of Internal Medicine, Division of Endocrinology, Metabolism, Clinical Chemistry and Pathobiochemie, University of Tuebingen, Tuebingen 72076
Corresponding Author: caweiger{at}med.uni-tuebingen.de
The exercise-induced interleukin (IL)-6 production and secretion within skeletal muscle fibers has raised the question of a putative tissue-specific function of IL-6 in the energy metabolism of the muscle during and after the exercise. In the present study we followed the hypothesis that IL-6 signaling may directly interact with insulin receptor substrate (IRS)-1 a keystone in the insulin signaling cascade. We show that IL-6 induces a rapid recruitment of IRS-1 to the IL-6 receptor complex in cultured skeletal muscle cells. Moreover, IL-6 induces a rapid and transient phosphorylation of Ser-318 of IRS-1 in muscle cells and in muscle tissue, but not in the liver of IL-6 treated mice, probably via the IL-6-induced co-recruitment of PKC-d. This Ser-318 phosphorylation improves insulin-stimulated Akt phosphorylation and glucose uptake in myotubes, since transfection with a IRS-1/Glu-318 mutant simulating a permanent phospho-Ser-318 modification increased Akt phosphorylation and glucose uptake. Noteworthy, two inhibitory mechanisms of IL-6 on insulin action, phosphorylation of the inhibitory Ser-307 residue of IRS-1 and induction of SOCS-3 expression, were only found in liver, but not in muscle of IL-6-treated mice. Thus, the data provide evidence for a possible molecular mechanism of the physiological metabolic effects of IL-6 in skeletal muscle, thereby exerting short-term beneficial effects on insulin action.
J. Biol. Chem, 10.1074/jbc.M509782200
Submitted on September 6, 2005
Accepted on January 17, 2006
Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Hoene, R. Lehmann, A. M. Hennige, A. K. Pohl, H. U. Haring, E. D. Schleicher, and C. Weigert Acute regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single bout of treadmill exercise J. Physiol., January 1, 2009; 587(1): 241 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Weigert, M. Kron, H. Kalbacher, A. K. Pohl, H. Runge, H.-U. Haring, E. Schleicher, and R. Lehmann Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells Mol. Endocrinol., December 1, 2008; 22(12): 2729 - 2740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Pedersen and M. A. Febbraio Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6 Physiol Rev, October 1, 2008; 88(4): 1379 - 1406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Peter, C. Weigert, H. Staiger, K. Rittig, A. Cegan, P. Lutz, F. Machicao, H.-U. Haring, and E. Schleicher Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity Am J Physiol Endocrinol Metab, August 1, 2008; 295(2): E339 - E349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. H. Mortensen, K. Andersen, C. Fischer, A. R. Nielsen, S. Nielsen, T. Akerstrom, M.-b. Aastrom, R. Borup, and B. K. Pedersen Calprotectin is released from human skeletal muscle tissue during exercise J. Physiol., July 15, 2008; 586(14): 3551 - 3562. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Schmitz-Peiffer and T. J. Biden Protein Kinase C Function in Muscle, Liver, and {beta}-Cells and Its Therapeutic Implications for Type 2 Diabetes Diabetes, July 1, 2008; 57(7): 1774 - 1783. [Full Text] [PDF]
|
|
|
|
 |
|
 R. S. Waraich, C. Weigert, H. Kalbacher, A. M. Hennige, S. Z. Lutz, H.-U. Haring, E. D. Schleicher, W. Voelter, and R. Lehmann Phosphorylation of Ser357 of Rat Insulin Receptor Substrate-1 Mediates Adverse Effects of Protein Kinase C-{delta} on Insulin Action in Skeletal Muscle Cells J. Biol. Chem., April 25, 2008; 283(17): 11226 - 11233. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K A. H Iwen, O. Senyaman, A. Schwartz, M. Drenckhan, B. Meier, D. Hadaschik, and J. Klein Melanocortin crosstalk with adipose functions: ACTH directly induces insulin resistance, promotes a pro-inflammatory adipokine profile and stimulates UCP-1 in adipocytes J. Endocrinol., March 1, 2008; 196(3): 465 - 472. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Wei, K. Chen, A. T. Whaley-Connell, C. S. Stump, J. A. Ibdah, and J. R. Sowers Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R673 - R680. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Glund, A. Deshmukh, Y. C. Long, T. Moller, H. A. Koistinen, K. Caidahl, J. R. Zierath, and A. Krook Interleukin-6 Directly Increases Glucose Metabolism in Resting Human Skeletal Muscle Diabetes, June 1, 2007; 56(6): 1630 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Mooney COUNTERPOINT: INTERLEUKIN-6 DOES NOT HAVE A BENEFICIAL ROLE IN INSULIN SENSITIVITY AND GLUCOSE HOMEOSTASIS J Appl Physiol, February 1, 2007; 102(2): 816 - 818. [Full Text] [PDF]
|
|
|
|
|
|
E. E. Spangenburg, S. E. Shoelson, C. Weigert, R. Lehmann, E. D. Schleicher, J.-O. Jansson, V. Wallenius, J.-P. Bastard, C. Lagathu, M. Caron, et al. Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis J Appl Physiol, February 1, 2007; 102(2): 820 - 823. [Full Text] [PDF]
|
|
|
|
|
|
B. K. Pedersen, M. A. Febbraio, and R. A. Mooney Interleukin-6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis J Appl Physiol, February 1, 2007; 102(2): 814 - 816. [Full Text] [PDF]
|
|
|
|
|
|
L. Al-Khalili, K. Bouzakri, S. Glund, F. Lonnqvist, H. A. Koistinen, and A. Krook Signaling Specificity of Interleukin-6 Action on Glucose and Lipid Metabolism in Skeletal Muscle Mol. Endocrinol., December 1, 2006; 20(12): 3364 - 3375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Carey, G. R. Steinberg, S. L. Macaulay, W. G. Thomas, A. G. Holmes, G. Ramm, O. Prelovsek, C. Hohnen-Behrens, M. J. Watt, D. E. James, et al. Interleukin-6 Increases Insulin-Stimulated Glucose Disposal in Humans and Glucose Uptake and Fatty Acid Oxidation In Vitro via AMP-Activated Protein Kinase. Diabetes, October 1, 2006; 55(10): 2688 - 2697. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |