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Papers In Press, published online ahead of print January 5, 2006
of Laboratory Medicine, div. of Experimental Pathology, Lund University, Malmö SE-205 02
Corresponding Author: anita.sjolander{at}exppat.mas.lu.se
Increased levels of the inflammatory mediator leukotriene D4 (LTD4) are present at sites of inflammatory bowel disease, and such areas also exhibit an increased risk for subsequent cancer development. It is known that LTD4 affects the expression of many proteins that influence survival and proliferation of intestinal epithelial cells. We demonstrate here that following LTD4 exposure, beta-catenin translocates to the nucleus where it signals activation of the TCF/LEF family of transcription factors. These events are mediated via a PI-3 kinase-dependent phosphorylation of the inhibitory Ser-9 residue of GSK-3beta. We also show that in the presence of LTD4, free beta-catenin translocates to the mitochondria where it associates with the cell survival protein Bcl-2. We hypothesize that LTD4 may enhance cell survival via activation of beta-catenin signaling, in particular, by promoting the association of beta-catenin with Bcl-2 in the mitochondria. Similar to Wnt-1 signaling, LTD4 signals an increased level of free beta-catenin and elevated TCF/LEF promotor activity. This work in intestinal epithelial cells further lends credence to the idea that inflammatory signaling pathways are intrinsically linked with potential oncogenic signals involved in cell survival and apoptosis.
J. Biol. Chem, 10.1074/jbc.M509999200
Submitted on September 12, 2005
Revised on January 4, 2006
Accepted on January 5, 2006
The inflammatory mediator leukotriene D4 induces
-catenin signaling and its association with anti-apoptotic Bcl-2 in intestinal epithelial cells
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