Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on June 16, 2006
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
281/24/16707    most recent
M510233200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Marjuki, H.
Right arrow Articles by Pleschka, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Marjuki, H.
Right arrow Articles by Pleschka, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print April 11, 2006
J. Biol. Chem, 10.1074/jbc.M510233200
Submitted on September 16, 2005
Accepted on April 11, 2006

Membrane accumulation of influenza a virus hemagglutinin triggers nuclear export of the viral genome via PKCalpha mediated activation of ERK signaling

Henju Marjuki, Mohammad I. Alam, Christina Ehrhardt, Ralf Wagner, Oliver Planz, Hans- D. Klenk, Stephan Ludwig, and Stephan Pleschka

Medicine, Institute for Medical Virology, Giessen D-35392

Corresponding Author: stephan.pleschka{at}mikro.bio.uni-giessen.de

Replication and transcription of the influenza virus genome takes place exclusively within the nucleus of the infected cells. The viral RNA genome, polymerase subunits and nucleoprotein form ribonucleoprotein-complexes (RNPs). Late in the infectious cycle RNPs have to be exported from the nucleus to be enwrapped into budding progeny virions at the cell membrane. This process requires viral activation of the cellular Raf/MEK/ERK kinase (MAPK) signaling cascade that is activated late in the infection cycle. Accordingly, block of the cascade results in retardation of RNP export and reduced titers of progeny virus. In the present study we have analyzed the importance of cell membrane association of the viral hemagglutinin (HA) glycoprotein for viral MAPK activation. We show that HA membrane accumulation and its tight association with lipid-raft domains triggers activation of the MAPK cascade via PKCalpha activation and induces RNP export. This may represent an auto-regulative mechanism that coordinates timing of RNP export to a point when all viral components are ready for virus budding.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Virol.Home page
L. A. Moser and S. Schultz-Cherry
Suppression of Astrovirus Replication by an ERK1/2 Inhibitor
J. Virol., August 1, 2008; 82(15): 7475 - 7482.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. Takahashi, K. Murakami, M. Nagakura, H. Kishita, S. Watanabe, K. Honke, K. Ogura, T. Tai, K. Kawasaki, D. Miyamoto, et al.
Sulfatide Is Required for Efficient Replication of Influenza A Virus
J. Virol., June 15, 2008; 82(12): 5940 - 5950.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement