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M512943200v1
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Papers In Press, published online ahead of print March 8, 2006
J. Biol. Chem, 10.1074/jbc.M512943200
Submitted on December 5, 2005
Revised on February 27, 2006
Accepted on March 8, 2006

Rosiglitazone controls fatty acid cycling in human adipose tissue by means of glyceroneogenesis and glycerol phosphorylation

Stéphanie Leroyer, Joan Tordjman, Geneviève Chauvet, Joëlle Quette, Charles Chapron, Claude Forest, and Bénédicte Antoine

INSERM U 530 - Université Paris5, Centre universitaire - U.F.R. Biomédicale, Paris 75006

Corresponding Author: benedicte.antoine{at}biomedicale.univ-paris5.fr

Control of fatty acid homeostasis is crucial to prevent insulin resistance. During fasting, plasma fatty acid level depends on triglycerides lipolysis and fatty acid re-esterification within fat cells. In rodents, Rosiglitazone (Rosi) control fatty acid homeostasis by stimulating two pathways in the adipocytes, glyceroneogenesis and glycerol phosphorylation that provide the glycerol-3-phosphate necessary for fatty acid re-esterification. Here, we analysed the functionality of both pathways for controlling fatty acid release in subcutaneous adipose tissue samples from lean and obese women before and after Rosi ex vivo treatment. In controls, pyruvate, used as a substrate of glyceroneogenesis, could contribute up to 65% of the fatty acid reesterified after basal lipolysis whereas glycerol phosphorylation account for only 14 +/- 9 %. However, efficiency of glyceroneogenesis is diminishing when women body mass index (BMI) increase. After Rosi treatment, increase of either pyruvate- or glycerol- dependent fatty acid re-esterification is strictly correlated to that of Phosphoenolpyruvate carboxykinase and Glycerolkinase, the key-enzymes of each pathway but depends on women BMI. While the rosi-responsiveness of glyceroneogenesis is rather constant according to women BMI, glycerol phosphorylation is mostly enhanced in lean women (BMI<27). Overall, these data indicate that, whereas glyceroneogenesis is more utilized than glycerol phosphorylation for fatty acid re-esterification in human subcutaneous adipose tissue in physiological situation, both are sollicited in response to Rosi but with lower efficiency when BMI increased.


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