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M605503200v1
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Papers In Press, published online ahead of print September 26, 2006
J. Biol. Chem, 10.1074/jbc.M605503200
Submitted on June 8, 2006
Revised on September 22, 2006
Accepted on September 26, 2006

BDNF activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade

Yupeng Wang, Bing Su, and Zhengui Xia

Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105

Corresponding Author: zxia{at}u.washington.edu

The extracellular signal-regulated kinase 5 (ERK5) is activated in neurons of the central nervous system by neurotrophins including brain-derived neurotrophic factor (BDNF). Although MEK5 is known to mediate BDNF stimulation of ERK5 in central nervous system neurons, other upstream signaling components have not been identified. Here, we report that BDNF induces a sustained activation of ERK5 in rat cortical neurons and activates Rap1, a small GTPase, as well as MEKK2, a MEK5 kinase. Our data indicate that activation of Rap1 or MEKK2 is sufficient to stimulate ERK5, while inhibition of either Rap1 or MEKK2 attenuates BDNF activation of ERK5. Furthermore, BDNF stimulation of MEKK2 is regulated by Rap1. Our evidence also indicates that Ras and MEKK3, a MEK5 kinase in non-neuronal cells, do not play a significant role in BDNF activation of ERK5. This study identifies Rap1 and MEKK2 as critical upstream signaling molecules mediating BDNF stimulation of ERK5 in central nervous system neurons.


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