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M608266200v1
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Papers In Press, published online ahead of print December 29, 2006
J. Biol. Chem, 10.1074/jbc.M608266200
Submitted on August 29, 2006
Revised on November 28, 2006
Accepted on December 29, 2006

Unique ability of activated CD4+ T cells but not rested effectors to migrate to non-lymphoid sites in the absence of inflammation

Javed N. Agrewala, Deborah M. Brown, Nancy M. Lepak, Debra Duso, Gail Huston, and Susan L. Swain

Trudeau Institute, Saranac Lake, NY 12983

Corresponding Author: sswain{at}northnet.org

Recent studies suggest that effector T cells generated by immune responses migrate to multiple non-lymphoid, sites, even those without apparent expression of antigen or inflammation. To investigate the ability of distinct CD4+ T lymphocyte subsets to enter and persist in non-lymphoid, non-inflammed compartments, we examined the migration and persistence of naive, effector and rested effector CD4+ T cells generated in vitro following transfer to non-immunized adoptive hosts. Th1 and Th2 effectors migrated to both lymphoid and non-lymphoid organs (peritoneum, fat pads, lung). In contrast, rested effectors and naive cells migrated only to lymphoid areas. Adhesion molecule expression, but not chemokine receptor expression correlated with the ability to enter non-lymphoid sites. Donor cells persisted longer in lymphoid than in non-lymphoid sites. When hosts with naïve and memory donor cells were challenged with antigen, effectors developed in situ which also migrated to non-lymphoid sites. Memory cells showed an accelerated shift to non-lymphoid migration, in keeping with memory effector formation. These results suggest that only recently activated effector T cells can disperse to non-lymphoid sites in the absence of antigen and inflammation, and that as effectors return to rest they lose this ability. These data also argue that memory cells in lymphoid sites are longer lived and not in equilibrium with those in non-lymphoid sites.


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