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Addition or Correction for Ruetz et al., J. Biol. Chem. 271 (8) 4154-4160.
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J Biol Chem, Vol. 274, Issue 4, 2592a-2592, January 22, 1999


Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae.

Stephan Ruetz, Martine Brault, Christina Kast, Charles Hemenway, Joseph Heitman, Caroline E. Grant, Susan P. C. Cole, Roger G. Deeley, and Philippe Gros

We have been unable to reproduce complementation of the yeast Saccharomyces cerevisiae ste6 mutant by the human MRP gene in 200 new yeast transformants tested. Additional studies suggest that the original MRP-associated mating activity was caused by contaminating STE6 sequences that were detected by Southern blotting in frozen vials of MRP transformants from that period. We were unable to reproduce high levels of Adriamycin and valinomycin resistance in MRP transformants of yeast strain VASY. Additional experiments suggest that MRP-mediated high level resistance to these two drugs was associated with contamination of yeast cultures with a multidrug-resistant microbial contaminant. Finally, we have been able to reproducibly observe MRP-mediated drug resistance to FK506, but only in the VASY strain (rad52, erg6) and not in the JPY201 strain. Thus, we are retracting the above manuscript (with the exception of MRP-mediated FK506 resistance). Please do not hesitate to contact P. Gros (gros{at}med.mcgill.ca) should you need additional information or wish to discuss further any aspect of this work.


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