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J. Biol. Chem., Vol. 280, Issue 51, 99952, December 23, 2005

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A NO-vel Class of Bioactive Lipids

Fatty acids are often oxidized by the body to convert them into potent signaling molecules. These oxidation reactions yield products that are involved in processes such as immune responses, neurotransmission, and the regulation of cell growth. Studies have also shown that nitric oxide (·NO) and other oxides of nitrogen can interact with lipid oxidation pathways to form nitrated fatty acids.

Nitrated oleic and linoleic acids induce adipogenesis.

In this Paper of the Week, Paul R. S. Baker and colleagues show that nitroalkene derivatives of all principal unsaturated fatty acids are present in human blood and urine. In addition to potentially serving as NO donors, and thus providing a buffer system that permits the diverse downstream biological signaling of NO, the nitrated fatty acid species also appear to serve as potent endogenous peroxisome proliferator-activated receptor (PPAR) agonists. PPAR signaling is widely involved in metabolic pathways involved in fat metabolism, vascular biology, carbohydrate metabolism, and inflammation. The demonstration of this novel class of ligands as abundant species generated by inflammatory pathways thus has wide ranging importance to a diverse audience.

FOOTNOTES

See referenced article, J. Biol. Chem. 2005, 280, 42464–42475

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Related Collections Papers Of The Week Social Bookmarking                      What's this?