JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.C100357200 on August 1, 2001

J. Biol. Chem., Vol. 276, Issue 38, 35235-35238, September 21, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/38/35235    most recent
C100357200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gu, Y.
Right arrow Articles by Ihara, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gu, Y.
Right arrow Articles by Ihara, Y.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

ACCELERATED PUBLICATION
Distinct Intramembrane Cleavage of the beta -Amyloid Precursor Protein Family Resembling gamma -Secretase-like Cleavage of Notch*

Yongjun GuDagger §, Hiroaki MisonouDagger §, Toru SatoDagger , Naoshi Dohmae||, Koji Takio||, and Yasuo IharaDagger §**

From the Dagger  Department of Neuropathology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, § Core Research and Evolutional Science and Technology, Japan Science and Technology Corporation, Kawaguchi 332-0012, and || Division of Biomolecular Characterization, Institute of Physical and Chemical Research (RIKEN), Wako 351-0198, Japan

The intramembrane cleavage of beta -amyloid precursor protein by gamma -secretase is the final step in the generation of amyloid beta -protein. A 59- or 57-residue C-terminal fragment called CTFgamma is produced concomitantly. Putative CTFgamma generated in rat brain membrane preparations was purified and sequenced. Instead of CTFgamma , shorter 50- and 49-residue fragments were identified. In addition, we found similar C-terminal fragments of beta -amyloid precursor-like proteins 1 and 2; these were also cleaved at corresponding sites. This newly identified cleavage occurs at a site two to five residues inside the cytoplasmic membrane boundary, which is very similar to gamma -secretase-like cleavage of Notch 1.

* This work was supported in part by a grant-in-aid for Scientific Research on Priority Areas (C), Advanced Brain Science Project, from the Ministry of Education, Culture, Sports, Science and Technology, Japan.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Present address: Dept. of Medicine (Neurology), Center for Research into Neurodegenerative Diseases, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

** To whom correspondence should be addressed: Dept. of Neuropathology, Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan. Tel.: 81-3-5841-3541; Fax: 81-3-5800-6852; E-mail: yihara@m.u-tokyo.ac.jp.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
S. Osawa, S. Funamoto, M. Nobuhara, S. Wada-Kakuda, M. Shimojo, S. Yagishita, and Y. Ihara
Phosphoinositides Suppress {gamma}-Secretase in Both the Detergent-soluble and -insoluble States
J. Biol. Chem., July 11, 2008; 283(28): 19283 - 19292.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Shimojo, N. Sahara, T. Mizoroki, S. Funamoto, M. Morishima-Kawashima, T. Kudo, M. Takeda, Y. Ihara, H. Ichinose, and A. Takashima
Enzymatic Characteristics of I213T Mutant Presenilin-1/{gamma}-Secretase in Cell Models and Knock-in Mouse Brains: FAMILIAL ALZHEIMER DISEASE-LINKED MUTATION IMPAIRS {gamma}-SITE CLEAVAGE OF AMYLOID PRECURSOR PROTEIN C-TERMINAL FRAGMENT {beta}
J. Biol. Chem., June 13, 2008; 283(24): 16488 - 16496.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Zhang, Y. Dong, G. Zhang, R. D. Moir, W. Xia, Y. Yue, M. Tian, D. J. Culley, G. Crosby, R. E. Tanzi, et al.
The Inhalation Anesthetic Desflurane Induces Caspase Activation and Increases Amyloid {beta}-Protein Levels under Hypoxic Conditions
J. Biol. Chem., May 2, 2008; 283(18): 11866 - 11875.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
R. A. Sharples, L. J. Vella, R. M. Nisbet, R. Naylor, K. Perez, K. J. Barnham, C. L. Masters, and A. F. Hill
Inhibition of {gamma}-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
FASEB J, May 1, 2008; 22(5): 1469 - 1478.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Kaden, L.-M. Munter, M. Joshi, C. Treiber, C. Weise, T. Bethge, P. Voigt, M. Schaefer, M. Beyermann, B. Reif, et al.
Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect {beta}-Secretase Cleavage of APP
J. Biol. Chem., March 14, 2008; 283(11): 7271 - 7279.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Yagishita, M. Morishima-Kawashima, S. Ishiura, and Y. Ihara
A 46 Is Processed to A 40 and A 43, but Not to A 42, in the Low Density Membrane Domains
J. Biol. Chem., January 11, 2008; 283(2): 733 - 738.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Hoshino, T. Nakaya, T. Homan, K.-i. Tanaka, Y. Sugimoto, W. Araki, M. Narita, S. Narumiya, T. Suzuki, and T. Mizushima
Involvement of Prostaglandin E2 in Production of Amyloid-beta Peptides Both in Vitro and in Vivo
J. Biol. Chem., November 9, 2007; 282(45): 32676 - 32688.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Vingtdeux, M. Hamdane, A. Loyens, P. Gele, H. Drobeck, S. Begard, M.-C. Galas, A. Delacourte, J.-C. Beauvillain, L. Buee, et al.
Alkalizing Drugs Induce Accumulation of Amyloid Precursor Protein By-products in Luminal Vesicles of Multivesicular Bodies
J. Biol. Chem., June 22, 2007; 282(25): 18197 - 18205.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Uemura, A. Kuzuya, Y. Shimozono, N. Aoyagi, K. Ando, S. Shimohama, and A. Kinoshita
GSK3beta Activity Modifies the Localization and Function of Presenilin 1
J. Biol. Chem., May 25, 2007; 282(21): 15823 - 15832.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Xie, Y. Dong, U. Maeda, W. Xia, and R. E. Tanzi
RNA Interference Silencing of the Adaptor Molecules ShcC and Fe65 Differentially Affect Amyloid Precursor Protein Processing and Abeta Generation
J. Biol. Chem., February 16, 2007; 282(7): 4318 - 4325.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Z. Xie, Y. Dong, U. Maeda, R. D. Moir, W. Xia, D. J. Culley, G. Crosby, and R. E. Tanzi
The Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Amyloid {beta}-Protein Accumulation
J. Neurosci., February 7, 2007; 27(6): 1247 - 1254.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-H. Kuan, T. Gruebl, P. Soba, S. Eggert, I. Nesic, S. Back, J. Kirsch, K. Beyreuther, and S. Kins
PAT1a Modulates Intracellular Transport and Processing of Amyloid Precursor Protein (APP), APLP1, and APLP2
J. Biol. Chem., December 29, 2006; 281(52): 40114 - 40123.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Alves da Costa, C. Sunyach, R. Pardossi-Piquard, J. Sevalle, B. Vincent, N. Boyer, T. Kawarai, N. Girardot, P. St. George-Hyslop, and F. Checler
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.
J. Neurosci., June 7, 2006; 26(23): 6377 - 6385.
[Abstract] [Full Text] [PDF]

Home page
 GENES CELLSHome page
T. Nakaya and T. Suzuki
Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD
Genes Cells, June 1, 2006; 11(6): 633 - 645.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Kakuda, S. Funamoto, S. Yagishita, M. Takami, S. Osawa, N. Dohmae, and Y. Ihara
Equimolar Production of Amyloid beta-Protein and Amyloid Precursor Protein Intracellular Domain from beta-Carboxyl-terminal Fragment by {gamma}-Secretase
J. Biol. Chem., May 26, 2006; 281(21): 14776 - 14786.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Sumioka, S. Nagaishi, T. Yoshida, A. Lin, M. Miura, and T. Suzuki
Role of 14-3-3{gamma} in FE65-dependent Gene Transactivation Mediated by the Amyloid {beta}-Protein Precursor Cytoplasmic Fragment
J. Biol. Chem., December 23, 2005; 280(51): 42364 - 42374.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Zhao, M.-Z. Cui, G. Mao, Y. Dong, J. Tan, L. Sun, and X. Xu
{gamma}-Cleavage Is Dependent on {zeta}-Cleavage during the Proteolytic Processing of Amyloid Precursor Protein within Its Transmembrane Domain
J. Biol. Chem., November 11, 2005; 280(45): 37689 - 37697.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
K. A. Ryan and S. W. Pimplikar
Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain
J. Cell Biol., October 24, 2005; 171(2): 327 - 335.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Y. Kim, L. A. M. Ingano, B. W. Carey, W. H. Pettingell, and D. M. Kovacs
Presenilin/{gamma}-Secretase-mediated Cleavage of the Voltage-gated Sodium Channel {beta}2-Subunit Regulates Cell Adhesion and Migration
J. Biol. Chem., June 17, 2005; 280(24): 23251 - 23261.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
W. T. Kimberly, J. B. Zheng, T. Town, R. A. Flavell, and D. J. Selkoe
Physiological Regulation of the {beta}-Amyloid Precursor Protein Signaling Domain by c-Jun N-Terminal Kinase JNK3 during Neuronal Differentiation
J. Neurosci., June 8, 2005; 25(23): 5533 - 5543.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-W. Kim, S.-C. Ho, S.-J. Hong, K. M. Kim, E. C. So, M. Christoffolete, and J. W. Harney
A Novel Mechanism of Thyroid Hormone-dependent Negative Regulation by Thyroid Hormone Receptor, Nuclear Receptor Corepressor (NCoR), and GAGA-binding Factor on the Rat CD44 Promoter
J. Biol. Chem., April 15, 2005; 280(15): 14545 - 14555.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Xie, D. M. Romano, and R. E. Tanzi
RNA Interference-mediated Silencing of X11{alpha} and X11{beta} Attenuates Amyloid {beta}-Protein Levels via Differential Effects on {beta}-Amyloid Precursor Protein Processing
J. Biol. Chem., April 15, 2005; 280(15): 15413 - 15421.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N. Sawamura, T. Sawamura-Yamamoto, Y. Ozeki, C. A. Ross, and A. Sawa
A form of DISC1 enriched in nucleus: Altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse
PNAS, January 25, 2005; 102(4): 1187 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
Y. Qi-Takahara, M. Morishima-Kawashima, Y. Tanimura, G. Dolios, N. Hirotani, Y. Horikoshi, F. Kametani, M. Maeda, T. C. Saido, R. Wang, et al.
Longer Forms of Amyloid {beta} Protein: Implications for the Mechanism of Intramembrane Cleavage by {gamma}-Secretase
J. Neurosci., January 12, 2005; 25(2): 436 - 445.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Zhao, G. Mao, J. Tan, Y. Dong, M.-Z. Cui, S.-H. Kim, and X. Xu
Identification of a New Presenilin-dependent {zeta}-Cleavage Site within the Transmembrane Domain of Amyloid Precursor Protein
J. Biol. Chem., December 3, 2004; 279(49): 50647 - 50650.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Cervantes, C. A. Saura, E. Pomares, R. Gonzalez-Duarte, and G. Marfany
Functional Implications of the Presenilin Dimerization: RECONSTITUTION OF {gamma}-SECRETASE ACTIVITY BY ASSEMBLY OF A CATALYTIC SITE AT THE DIMER INTERFACE OF TWO CATALYTICALLY INACTIVE PRESENILINS
J. Biol. Chem., August 27, 2004; 279(35): 36519 - 36529.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Xie, D. M. Romano, D. M. Kovacs, and R. E. Tanzi
Effects of RNA Interference-mediated Silencing of {gamma}-Secretase Complex Components on Cell Sensitivity to Caspase-3 Activation
J. Biol. Chem., August 13, 2004; 279(33): 34130 - 34137.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Zou, B. Chung, T. Nguyen, S. Mentone, B. Thomson, and D. Biemesderfer
Linking Receptor-mediated Endocytosis and Cell Signaling: EVIDENCE FOR REGULATED INTRAMEMBRANE PROTEOLYSIS OF MEGALIN IN PROXIMAL TUBULE
J. Biol. Chem., August 13, 2004; 279(33): 34302 - 34310.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Araki, N. Miyagi, N. Kato, T. Yoshida, S. Wada, M. Nishimura, H. Komano, T. Yamamoto, B. De Strooper, K. Yamamoto, et al.
Coordinated Metabolism of Alcadein and Amyloid {beta}-Protein Precursor Regulates FE65-dependent Gene Transactivation
J. Biol. Chem., June 4, 2004; 279(23): 24343 - 24354.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Cao and T. C. Sudhof
Dissection of Amyloid-{beta} Precursor Protein-dependent Transcriptional Transactivation
J. Biol. Chem., June 4, 2004; 279(23): 24601 - 24611.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. S. Perkinton, C. L. Standen, K.-F. Lau, S. Kesavapany, H. L. Byers, M. Ward, D. M. McLoughlin, and C. C. J. Miller
The c-Abl Tyrosine Kinase Phosphorylates the Fe65 Adaptor Protein to Stimulate Fe65/Amyloid Precursor Protein Nuclear Signaling
J. Biol. Chem., May 21, 2004; 279(21): 22084 - 22091.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Eggert, K. Paliga, P. Soba, G. Evin, C. L. Masters, A. Weidemann, and K. Beyreuther
The Proteolytic Processing of the Amyloid Precursor Protein Gene Family Members APLP-1 and APLP-2 Involves {alpha}-, {beta}-, {gamma}-, and {epsilon}-Like Cleavages: MODULATION OF APLP-1 PROCESSING BY N-GLYCOSYLATION
J. Biol. Chem., April 30, 2004; 279(18): 18146 - 18156.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Sawamura, M. Ko, W. Yu, K. Zou, K. Hanada, T. Suzuki, J.-S. Gong, K. Yanagisawa, and M. Michikawa
Modulation of Amyloid Precursor Protein Cleavage by Cellular Sphingolipids
J. Biol. Chem., March 19, 2004; 279(12): 11984 - 11991.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. E. Roher, T. A. Kokjohn, C. Esh, N. Weiss, J. Childress, W. Kalback, D. C. Luehrs, J. Lopez, D. Brune, Y.-M. Kuo, et al.
The Human Amyloid-{beta} Precursor Protein770 Mutation V717F Generates Peptides Longer Than Amyloid-{beta}-(40-42) and Flocculent Amyloid Aggregates
J. Biol. Chem., February 13, 2004; 279(7): 5829 - 5836.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. G. Schulz, W. Annaert, J. Vandekerckhove, P. Zimmermann, B. De Strooper, and G. David
Syndecan 3 Intramembrane Proteolysis Is Presenilin/{gamma}-Secretase-dependent and Modulates Cytosolic Signaling
J. Biol. Chem., December 5, 2003; 278(49): 48651 - 48657.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. H. Schroeter, Ma. X. G. Ilagan, A. L. Brunkan, S. Hecimovic, Y.-m. Li, M. Xu, H. D. Lewis, M. T. Saxena, B. De Strooper, A. Coonrod, et al.
A presenilin dimer at the core of the {gamma}-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis
PNAS, October 28, 2003; 100(22): 13075 - 13080.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-M. Jung, S. Tan, N. Landman, K. Petrova, S. Murray, R. Lewis, P. K. Kim, D. S. Kim, S. H. Ryu, M. V. Chao, et al.
Regulated Intramembrane Proteolysis of the p75 Neurotrophin Receptor Modulates Its Association with the TrkA Receptor
J. Biol. Chem., October 24, 2003; 278(43): 42161 - 42169.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
M. Guo, E. J. Hong, J. Fernandes, S. L. Zipursky, and B. A. Hay
A reporter for amyloid precursor protein {gamma}-secretase activity in Drosophila
Hum. Mol. Genet., October 16, 2003; 12(20): 2669 - 2678.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-H. Kim, T. Ikeuchi, C. Yu, and S. S. Sisodia
Regulated Hyperaccumulation of Presenilin-1 and the "{gamma}-Secretase" Complex: EVIDENCE FOR DIFFERENTIAL INTRAMEMBRANOUS PROCESSING OF TRANSMEMBRANE SUBSTRATES
J. Biol. Chem., September 5, 2003; 278(36): 33992 - 34002.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Weggen, J. L. Eriksen, S. A. Sagi, C. U. Pietrzik, Todd. E. Golde, and E. H. Koo
A{beta}42-lowering Nonsteroidal Anti-inflammatory Drugs Preserve Intramembrane Cleavage of the Amyloid Precursor Protein (APP) and ErbB-4 Receptor and Signaling through the APP Intracellular Domain
J. Biol. Chem., August 15, 2003; 278(33): 30748 - 30754.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Sato, N. Dohmae, Y. Qi, N. Kakuda, H. Misonou, R. Mitsumori, H. Maruyama, E. H. Koo, C. Haass, K. Takio, et al.
Potential Link between Amyloid {beta}-Protein 42 and C-terminal Fragment {gamma} 49-99 of {beta}-Amyloid Precursor Protein
J. Biol. Chem., June 27, 2003; 278(27): 24294 - 24301.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
T. E. Golde and C. B. Eckman
Physiologic and Pathologic Events Mediated by Intramembranous and Juxtamembranous Proteolysis
Sci. Signal., March 4, 2003; 2003(172): re4 - re4.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. Grziwa, M. O. W. Grimm, C. L. Masters, K. Beyreuther, T. Hartmann, and S. F. Lichtenthaler
The Transmembrane Domain of the Amyloid Precursor Protein in Microsomal Membranes Is on Both Sides Shorter than Predicted
J. Biol. Chem., February 21, 2003; 278(9): 6803 - 6808.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Fluhrer, G. Multhaup, A. Schlicksupp, M. Okochi, M. Takeda, S. Lammich, M. Willem, G. Westmeyer, W. Bode, J. Walter, et al.
Identification of a beta -Secretase Activity, Which Truncates Amyloid beta -Peptide after Its Presenilin-dependent Generation
J. Biol. Chem., February 14, 2003; 278(8): 5531 - 5538.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Y. Kim, L. A. M. Ingano, and D. M. Kovacs
Nectin-1alpha , an Immunoglobulin-like Receptor Involved in the Formation of Synapses, Is a Substrate for Presenilin/gamma -Secretase-like Cleavage
J. Biol. Chem., December 13, 2002; 277(51): 49976 - 49981.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Lammich, M. Okochi, M. Takeda, C. Kaether, A. Capell, A.-K. Zimmer, D. Edbauer, J. Walter, H. Steiner, and C. Haass
Presenilin-dependent Intramembrane Proteolysis of CD44 Leads to the Liberation of Its Intracellular Domain and the Secretion of an Abeta -like Peptide
J. Biol. Chem., November 15, 2002; 277(47): 44754 - 44759.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. H. Scheinfeld, E. Ghersi, K. Laky, B. J. Fowlkes, and L. D'Adamio
Processing of beta -Amyloid Precursor-like Protein-1 and -2 by gamma -Secretase Regulates Transcription
J. Biol. Chem., November 8, 2002; 277(46): 44195 - 44201.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Komano, H. Shiraishi, Y. Kawamura, X. Sai, R. Suzuki, L. Serneels, M. Kawaichi, T. Kitamura, and K. Yanagisawa
A New Functional Screening System for Identification of Regulators for the Generation of Amyloid beta -Protein
J. Biol. Chem., October 11, 2002; 277(42): 39627 - 39633.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Chen, Y. Gu, H. Hasegawa, X. Ruan, S. Arawaka, P. Fraser, D. Westaway, H. Mount, and P. St George-Hyslop
Presenilin 1 Mutations Activate gamma 42-Secretase but Reciprocally Inhibit epsilon -Secretase Cleavage of Amyloid Precursor Protein (APP) and S3-Cleavage of Notch
J. Biol. Chem., September 20, 2002; 277(39): 36521 - 36526.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
J. Hardy and D. J. Selkoe
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
Science, July 19, 2002; 297(5580): 353 - 356.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Moehlmann, E. Winkler, X. Xia, D. Edbauer, J. Murrell, A. Capell, C. Kaether, H. Zheng, B. Ghetti, C. Haass, et al.
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production
PNAS, June 11, 2002; 99(12): 8025 - 8030.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Roncarati, N. Sestan, M. H. Scheinfeld, B. E. Berechid, P. A. Lopez, O. Meucci, J. C. McGlade, P. Rakic, and L. D'Adamio
The gamma -secretase-generated intracellular domain of beta -amyloid precursor protein binds Numb and inhibits Notch signaling
PNAS, May 14, 2002; 99(10): 7102 - 7107.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Zhang, W. Ye, R. Wang, M. S. Wolfe, B. D. Greenberg, and D. J. Selkoe
Proteolysis of Chimeric beta -Amyloid Precursor Proteins Containing the Notch Transmembrane Domain Yields Amyloid beta -like Peptides
J. Biol. Chem., April 19, 2002; 277(17): 15069 - 15075.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Edbauer, M. Willem, S. Lammich, H. Steiner, and C. Haass
Insulin-degrading Enzyme Rapidly Removes the beta -Amyloid Precursor Protein Intracellular Domain (AICD)
J. Biol. Chem., April 12, 2002; 277(16): 13389 - 13393.
[Abstract] [Full Text] [PDF]