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Papers In Press, published online ahead of print August 1, 2001
J. Biol. Chem, 10.1074/jbc.C100357200
Submitted on June 26, 2001
Revised on July 27, 2001
Accepted on August 1, 2001
-amyloid precursor protein family resembling 
-secretase-like cleavage of Notch
Department of Neuropathology, University of Tokyo, Tokyo 113-0033
Corresponding Author: yihara{at}m.u-tokyo.ac.jp
The intramembrane cleavage of 
-amyloid precursor protein by 
-secretase is the final step in the generation of amyloid -protein. A 59- or 57-residue C-terminal fragment called CTF is produced concomitantly. Putative CTF generated in rat brain membrane preparations was purified and sequenced. Instead of CTF, shorter 50- and 49-residue fragments were identified. In addition, we found similar C-terminal fragments of -amyloid precursor-like proteins 1 and 2; these were also cleaved at corresponding sites. This newly identified cleavage occurs at a site two to five residues inside the cytoplasmic membrane boundary, which is very similar to -secretase-like cleavage of Notch 1.
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|
|
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|
|
|
|
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|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 T. E. Golde and C. B. Eckman Physiologic and Pathologic Events Mediated by Intramembranous and Juxtamembranous Proteolysis Sci. Signal., March 4, 2003; 2003(172): re4 - re4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
 J. Hardy and D. J. Selkoe The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics Science, July 19, 2002; 297(5580): 353 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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