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Papers In Press, published online ahead of print January 30, 2001
Faculty of Pharmaceutical Sciences, Chiba University, Chiba, Chiba 263-8522
Corresponding Author: iga16077{at}p.chiba-u.ac.jp
The effects of polyamines on the synthesis of various
J. Biol. Chem, 10.1074/jbc.M011059200
Submitted on December 8, 2000
Revised on January 25, 2001
Accepted on January 29, 2001
Polyamine enhancement of the synthesis of adenylate cyclase at the translational level and the consequential stimulation of the synthesis of the RNA polymerase
28 subunit
subunits of RNA polymerase were studied using Western blot analysis. Synthesis of 28 was stimulated 4.0-fold and that of 38 was stimulated 2.3-fold by polyamines, whereas synthesis of other subunits was not influenced by polyamines. Stimulation of 28 synthesis was due to an increase in the level of cAMP, which occurred through polyamine stimulation of the synthesis of adenylate cyclase at the level of translation. Polyamines were found to increase the translation of adenylate cyclase mRNA by facilitating the UUG codon-dependent initiation. Analysis of RNA secondary structure suggests that exposure of the Shine-Dalgarno (SD) sequence of mRNA is a prerequisite for polyamine stimulation of the UUG codon-dependent initiation.
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