JBC Oz Biosciences

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

A more recent version of this article appeared on June 1, 2001
This Article
Right arrow Full Text (Accepted Manuscript)
Right arrow All Versions of this Article:
276/23/20523    most recent
M100679200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Paria, B. C.
Right arrow Articles by Dey, S. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Paria, B. C.
Right arrow Articles by Dey, S. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Papers In Press, published online ahead of print March 8, 2001
J. Biol. Chem, 10.1074/jbc.M100679200
Submitted on January 24, 2001
Revised on March 8, 2001
Accepted on March 8, 2001

Dysregulated cannabinoid signaling disrupts uterine receptivity for embryo implantation

B. C. Paria, H. Song, X. Wang, P. C. Schmid, R. J. Krebsbach, H. H. O. Schmid, Tom I. Bonner, Andeas Zimmer, and S. K. Dey

Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160

Corresponding Author: sdey{at}kumc.edu

The mechanisms by which synchronized embryonic development to the blastocyst stage, preparation of the uterus to the receptive state and reciprocal embryo-uterine interactions for implantation are coordinated are still unclear. We show here that preimplantation embryo development becomes asynchronous in mice deficient in cannabinoid receptor genes, brain-type (CB1) and/or spleen-type (CB2). Furthermore, while the levels of uterine anandamide (endocannabinoid) and blastocyst CB1 are coordinately downregulated with the onset of uterine receptivity and blastocyst activation prior to implantation, these levels remain high in the non-receptive uterus and dormant blastocysts during delayed implantation, and in pregnant leukemia inhibitory factor (LIF) deficient mice with implantation failure. The results suggest that a tight regulation of endocannabinoid signaling is important for synchronizing embryo development with uterine receptivity for implantation. Indeed, this is consistent with our finding that while experimentally induced sustained level of an exogenously administered natural cannabinoid inhibits implantation in wild-type mice, it fails to do so in CB1-/-/CB2-/- double mutant mice. The present study is clinically important because of the widely debated medicinal use of cannabinoids and their reported adverse effects on pregnancy.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
M.Y. Turco, K. Matsukawa, M. Czernik, V. Gasperi, N. Battista, L. Della Salda, P.A. Scapolo, P. Loi, M. Maccarrone, and G. Ptak
High levels of anandamide, an endogenous cannabinoid, block the growth of sheep preimplantation embryos by inducing apoptosis and reversible arrest of cell proliferation
Hum. Reprod., October 1, 2008; 23(10): 2331 - 2338.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. D. Mitchell, T. A. Sato, A. Wang, J. A. Keelan, A. P. Ponnampalam, and M. Glass
Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue- and CB1-receptor-specific mechanism
Am J Physiol Endocrinol Metab, February 1, 2008; 294(2): E352 - E356.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
A.H. Taylor, C. Ang, S.C. Bell, and J.C. Konje
The role of the endocannabinoid system in gametogenesis, implantation and early pregnancy
Hum. Reprod. Update, September 1, 2007; 13(5): 501 - 513.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. Rossi, V. Gasperi, R. Paro, D. Barsacchi, S. Cecconi, and M. Maccarrone
Follicle-Stimulating Hormone Activates Fatty Acid Amide Hydrolase by Protein Kinase A and Aromatase-Dependent Pathways in Mouse Primary Sertoli Cells
Endocrinology, March 1, 2007; 148(3): 1431 - 1439.
[Abstract] [Full Text] [PDF]

Home page
 ReproductionHome page
H. Song, K. Han, and H. Lim
Progesterone supplementation extends uterine receptivity for blastocyst implantation in mice
Reproduction, February 1, 2007; 133(2): 487 - 493.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
P. Pacher, S. Batkai, and G. Kunos
The Endocannabinoid System as an Emerging Target of Pharmacotherapy
Pharmacol. Rev., September 1, 2006; 58(3): 389 - 462.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
H. Wang, S. K. Dey, and M. Maccarrone
Jekyll and Hyde: Two Faces of Cannabinoid Signaling in Male and Female Fertility
Endocr. Rev., August 1, 2006; 27(5): 427 - 448.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M. Khare, A. H. Taylor, J. C. Konje, and S. C. Bell
{Delta}9-Tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription
Mol. Hum. Reprod., May 1, 2006; 12(5): 321 - 333.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
H. Schuel and L. J. Burkman
A Tale of Two Cells: Endocannabinoid-Signaling Regulates Functions of Neurons and Sperm
Biol Reprod, December 1, 2005; 73(6): 1078 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Guo, H. Wang, Y. Okamoto, N. Ueda, P. J. Kingsley, L. J. Marnett, H. H. O. Schmid, S. K. Das, and S. K. Dey
N-Acylphosphatidylethanolamine-hydrolyzing Phospholipase D Is an Important Determinant of Uterine Anandamide Levels during Implantation
J. Biol. Chem., June 24, 2005; 280(25): 23429 - 23432.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
O. M. H. Habayeb, A. H. Taylor, M. D. Evans, M. S. Cooke, D. J. Taylor, S. C. Bell, and J. C. Konje
Plasma Levels of the Endocannabinoid Anandamide in Women--A Potential Role in Pregnancy Maintenance and Labor?
J. Clin. Endocrinol. Metab., November 1, 2004; 89(11): 5482 - 5487.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
R. J. A. Helliwell, L. W. Chamley, K. Blake-Palmer, M. D. Mitchell, J. Wu, C. S. Kearn, and M. Glass
Characterization of the Endocannabinoid System in Early Human Pregnancy
J. Clin. Endocrinol. Metab., October 1, 2004; 89(10): 5168 - 5174.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
S. K. Dey, H. Lim, S. K. Das, J. Reese, B. C. Paria, T. Daikoku, and H. Wang
Molecular Cues to Implantation
Endocr. Rev., June 1, 2004; 25(3): 341 - 373.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M. Maccarrone, M. DeFelici, F.G. Klinger, N. Battista, F. Fezza, E. Dainese, G. Siracusa, and A. Finazzi-Agro
Mouse blastocysts release a lipid which activates anandamide hydrolase in intact uterus
Mol. Hum. Reprod., April 1, 2004; 10(4): 215 - 221.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Wang, H. Matsumoto, Y. Guo, B. C. Paria, R. L. Roberts, and S. K. Dey
Differential G protein-coupled cannabinoid receptor signaling by anandamide directs blastocyst activation for implantation
PNAS, December 9, 2003; 100(25): 14914 - 14919.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
O. Ueda, K. Yorozu, N. Kamada, K.-i. Jishage, Y. Kawase, Y. Toyoda, and H. Suzuki
Possible Expansion of "Window of Implantation" in Pseudopregnant Mice: Time of Implantation of Embryos at Different Stages of Development Transferred into the Same Recipient
Biol Reprod, September 1, 2003; 69(3): 1085 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Maccarrone, M. Bari, M. Di Rienzo, A. Finazzi-Agro, and A. Rossi
Progesterone Activates Fatty Acid Amide Hydrolase (FAAH) Promoter in Human T Lymphocytes through the Transcription Factor Ikaros: EVIDENCE FOR A SYNERGISTIC EFFECT OF LEPTIN
J. Biol. Chem., August 29, 2003; 278(35): 32726 - 32732.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Maccarrone, M. Di Rienzo, A. Finazzi-Agro, and A. Rossi
Leptin Activates the Anandamide Hydrolase Promoter in Human T Lymphocytes through STAT3
J. Biol. Chem., April 4, 2003; 278(15): 13318 - 13324.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. Maccarrone, S. Cecconi, G. Rossi, N. Battista, R. Pauselli, and A. Finazzi-Agro
Anandamide Activity and Degradation Are Regulated by Early Postnatal Aging and Follicle-Stimulating Hormone in Mouse Sertoli Cells
Endocrinology, January 1, 2003; 144(1): 20 - 28.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
B. C. Paria, J. Reese, S. K. Das, and S. K. Dey
Deciphering the Cross-Talk of Implantation: Advances and Challenges
Science, June 21, 2002; 296(5576): 2185 - 2188.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
A. C. Howlett, F. Barth, T. I. Bonner, G. Cabral, P. Casellas, W. A. Devane, C. C. Felder, M. Herkenham, K. Mackie, B. R. Martin, et al.
International Union of Pharmacology. XXVII. Classification of Cannabinoid Receptors
Pharmacol. Rev., June 1, 2002; 54(2): 161 - 202.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
M. Maccarrone, T. Bisogno, H. Valensise, N. Lazzarin, F. Fezza, C. Manna, V. Di Marzo, and A. Finazzi-Agro
Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer
Mol. Hum. Reprod., February 1, 2002; 8(2): 188 - 195.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.