| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print March 12, 2001
Dept. of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105
Corresponding Author: erich.gulbins{at}stjude.org
Clustering seems to be employed by many receptors for transmembrane signaling. Here, we show that acid sphingomyelinase (ASM)-released ceramide is essential for clustering of CD95. In vitro and in vivo, extracellularly-orientated ceramide, released upon CD95-triggered translocation of ASM to the plasma membrane outer surface, enabled clustering of CD95 in sphingolipid rich membrane rafts, and apoptosis induction. While ASM deficiency, destruction of rafts or neutralization of surface ceramide prevented CD95 clustering and apoptosis, natural ceramide only rescued ASM-deficient cells. The data suggest CD95-mediated clustering by ceramide is prerequisite for signaling and death.
J. Biol. Chem, 10.1074/jbc.M101207200
Submitted on February 7, 2001
Revised on March 8, 2001
Accepted on March 11, 2001
CD95 Signaling Via ceramide rich membrane rafts
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  E. L. Smith and E. H. Schuchman The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases FASEB J, October 1, 2008; 22(10): 3419 - 3431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, X. Li, A. Carpinteiro, and E. Gulbins Acid Sphingomyelinase Amplifies Redox Signaling in Pseudomonas aeruginosa-Induced Macrophage Apoptosis J. Immunol., September 15, 2008; 181(6): 4247 - 4254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, A. R. Sapuri-Butti, H. H. Aung, A. N. Parikh, and J. C. Rutledge Triglyceride-rich lipoprotein lipolysis increases aggregation of endothelial cell membrane microdomains and produces reactive oxygen species Am J Physiol Heart Circ Physiol, July 1, 2008; 295(1): H237 - H244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Henkes, B. T. Sullivan, M. P. Lynch, R. Kolesnick, D. Arsenault, M. Puder, J. S. Davis, and B. R. Rueda Acid sphingomyelinase involvement in tumor necrosis factor {alpha}-regulated vascular and steroid disruption during luteolysis in vivo PNAS, June 3, 2008; 105(22): 7670 - 7675. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Galvan, P. G. Camoletto, F. Cristofani, P. P. Van Veldhoven, and M. D. Ledesma Anomalous Surface Distribution of Glycosyl Phosphatidyl Inositol-anchored Proteins in Neurons Lacking Acid Sphingomyelinase Mol. Biol. Cell, February 1, 2008; 19(2): 509 - 522. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Reinehr, A. Sommerfeld, V. Keitel, S. Grether-Beck, and D. Haussinger Amplification of CD95 Activation by Caspase 8-induced Endosomal Acidification in Rat Hepatocytes J. Biol. Chem., January 25, 2008; 283(4): 2211 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Stel, B. ten Cate, S. Jacobs, J. W. Kok, D. C. J. Spierings, M. Dondorff, W. Helfrich, H. C. Kluin-Nelemans, L. F. M. H. de Leij, S. Withoff, et al. Fas Receptor Clustering and Involvement of the Death Receptor Pathway in Rituximab-Mediated Apoptosis with Concomitant Sensitization of Lymphoma B Cells to Fas-Induced Apoptosis J. Immunol., February 15, 2007; 178(4): 2287 - 2295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Gajate and F. Mollinedo Edelfosine and perifosine induce selective apoptosis in multiple myeloma by recruitment of death receptors and downstream signaling molecules into lipid rafts Blood, January 15, 2007; 109(2): 711 - 719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Sapora and B. Di Carlo Cell signalling mechanisms and the control of cell life and death Radiat Prot Dosimetry, December 1, 2006; 122(1-4): 210 - 220. [Full Text] [PDF]
|
|
|
|
|
|
Megha, O. Bakht, and E. London Cholesterol Precursors Stabilize Ordinary and Ceramide-rich Ordered Lipid Domains (Lipid Rafts) to Different Degrees: IMPLICATIONS FOR THE BLOCH HYPOTHESIS AND STEROL BIOSYNTHESIS DISORDERS J. Biol. Chem., August 4, 2006; 281(31): 21903 - 21913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-L. Hsiao, W.-S. Wang, P.-M. Chen, and Y. Su Overexpression of thymosin {beta}-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively Carcinogenesis, May 1, 2006; 27(5): 936 - 944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Nachbur, D. Kassahn, S. Yousefi, D. F. Legler, and T. Brunner Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts Blood, April 1, 2006; 107(7): 2790 - 2796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Cahuzac, W. Baum, V. Kirkin, F. Conchonaud, L. Wawrezinieck, D. Marguet, O. Janssen, M. Zornig, and A.-O. Hueber Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity Blood, March 15, 2006; 107(6): 2384 - 2391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Furne, V. Corset, Z. Herincs, N. Cahuzac, A.-O. Hueber, and P. Mehlen The dependence receptor DCC requires lipid raft localization for cell death signaling. PNAS, March 14, 2006; 103(11): 4128 - 4133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Pozo, M. Vales-Gomez, N. Mavaddat, S. C. Williamson, S. E. Chisholm, and H. Reyburn CD161 (Human NKR-P1A) Signaling in NK Cells Involves the Activation of Acid Sphingomyelinase J. Immunol., February 15, 2006; 176(4): 2397 - 2406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Gulbins and P. L. Li Physiological and pathophysiological aspects of ceramide Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R11 - R26. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Y. Zhang, F. Yi, G. Zhang, E. Gulbins, and P.-L. Li Lipid Raft Clustering and Redox Signaling Platform Formation in Coronary Arterial Endothelial Cells Hypertension, January 1, 2006; 47(1): 74 - 80. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Zaremberg, C. Gajate, L. M. Cacharro, F. Mollinedo, and C. R. McMaster Cytotoxicity of an Anti-cancer Lysophospholipid through Selective Modification of Lipid Raft Composition J. Biol. Chem., November 11, 2005; 280(45): 38047 - 38058. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tani, Y. Igarashi, and M. Ito Involvement of Neutral Ceramidase in Ceramide Metabolism at the Plasma Membrane and in Extracellular Milieu J. Biol. Chem., November 4, 2005; 280(44): 36592 - 36600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sobota, A. Strzelecka-Kiliszek, E. Gladkowska, K. Yoshida, K. Mrozinska, and K. Kwiatkowska Binding of IgG-Opsonized Particles to Fc{gamma}R Is an Active Stage of Phagocytosis That Involves Receptor Clustering and Phosphorylation J. Immunol., October 1, 2005; 175(7): 4450 - 4457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vial and R. J. Evans Disruption of Lipid Rafts Inhibits P2X1 Receptor-mediated Currents and Arterial Vasoconstriction J. Biol. Chem., September 2, 2005; 280(35): 30705 - 30711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Miyaji, Z.-X. Jin, S. Yamaoka, R. Amakawa, S. Fukuhara, S. B. Sato, T. Kobayashi, N. Domae, T. Mimori, E. T. Bloom, et al. Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis J. Exp. Med., July 18, 2005; 202(2): 249 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Grassme, A. Riehle, B. Wilker, and E. Gulbins Rhinoviruses Infect Human Epithelial Cells via Ceramide-enriched Membrane Platforms J. Biol. Chem., July 15, 2005; 280(28): 26256 - 26262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Wang, J. Silva, K. Krishnamurthy, E. Tran, B. G. Condie, and E. Bieberich Direct Binding to Ceramide Activates Protein Kinase C{zeta} before the Formation of a Pro-apoptotic Complex with PAR-4 in Differentiating Stem Cells J. Biol. Chem., July 15, 2005; 280(28): 26415 - 26424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Rotolo, J. Zhang, M. Donepudi, H. Lee, Z. Fuks, and R. Kolesnick Caspase-dependent and -independent Activation of Acid Sphingomyelinase Signaling J. Biol. Chem., July 15, 2005; 280(28): 26425 - 26434. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. S. Soderstrom, S. D. Nyberg, and J. E. Eriksson CD95 capping is ROCK-dependent and dispensable for apoptosis J. Cell Sci., May 15, 2005; 118(10): 2211 - 2223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Charruyer, S. Grazide, C. Bezombes, S. Muller, G. Laurent, and J.-P. Jaffrezou UV-C Light Induces Raft-associated Acid Sphingomyelinase and JNK Activation and Translocation Independently on a Nuclear Signal J. Biol. Chem., May 13, 2005; 280(19): 19196 - 19204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Henkler, E. Behrle, K. M. Dennehy, A. Wicovsky, N. Peters, C. Warnke, K. Pfizenmaier, and H. Wajant The extracellular domains of FasL and Fas are sufficient for the formation of supramolecular FasL-Fas clusters of high stability J. Cell Biol., March 28, 2005; 168(7): 1087 - 1098. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Zhang, E. G. Teggatz, A.-P. Zou, W. B. Campbell, and P.-L. Li Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2-{middle dot} production in the intact coronary endothelium Am J Physiol Heart Circ Physiol, February 1, 2005; 288(2): H686 - H694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-Y. Fan, L. H. Ly, R. Barhoumi, D. N. McMurray, and R. S. Chapkin Dietary Docosahexaenoic Acid Suppresses T Cell Protein Kinase C{theta} Lipid Raft Recruitment and IL-2 Production J. Immunol., November 15, 2004; 173(10): 6151 - 6160. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Scheel-Toellner, K. Wang, R. Craddock, P. R. Webb, H. M. McGettrick, L. K. Assi, N. Parkes, L. E. Clough, E. Gulbins, M. Salmon, et al. Reactive oxygen species limit neutrophil life span by activating death receptor signaling Blood, October 15, 2004; 104(8): 2557 - 2564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Abdel Shakor, K. Kwiatkowska, and A. Sobota Cell Surface Ceramide Generation Precedes and Controls Fc{gamma}RII Clustering and Phosphorylation in Rafts J. Biol. Chem., August 27, 2004; 279(35): 36778 - 36787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Gajate, E. del Canto-Janez, A. U. Acuna, F. Amat-Guerri, E. Geijo, A. M. Santos-Beneit, R. J. Veldman, and F. Mollinedo Intracellular Triggering of Fas Aggregation and Recruitment of Apoptotic Molecules into Fas-enriched Rafts in Selective Tumor Cell Apoptosis J. Exp. Med., August 2, 2004; 200(3): 353 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Switzer, Y.-Y. Fan, N. Wang, D. N. McMurray, and R. S. Chapkin Dietary n-3 polyunsaturated fatty acids promote activation-induced cell death in Th1-polarized murine CD4+ T-cells J. Lipid Res., August 1, 2004; 45(8): 1482 - 1492. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Lacour, A. Hammann, S. Grazide, D. Lagadic-Gossmann, A. Athias, O. Sergent, G. Laurent, P. Gambert, E. Solary, and M.-T. Dimanche-Boitrel Cisplatin-Induced CD95 Redistribution into Membrane Lipid Rafts of HT29 Human Colon Cancer Cells Cancer Res., May 15, 2004; 64(10): 3593 - 3598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Megha and E. London Ceramide Selectively Displaces Cholesterol from Ordered Lipid Domains (Rafts): IMPLICATIONS FOR LIPID RAFT STRUCTURE AND FUNCTION J. Biol. Chem., March 12, 2004; 279(11): 9997 - 10004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gupta, R. Natarajan, S. G. Payne, E. J. Studer, S. Spiegel, P. Dent, and P. B. Hylemon Deoxycholic Acid Activates the c-Jun N-terminal Kinase Pathway via FAS Receptor Activation in Primary Hepatocytes: ROLE OF ACIDIC SPHINGOMYELINASE-MEDIATED CERAMIDE GENERATION IN FAS RECEPTOR ACTIVATION J. Biol. Chem., February 13, 2004; 279(7): 5821 - 5828. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Delmas, C. Rebe, S. Lacour, R. Filomenko, A. Athias, P. Gambert, M. Cherkaoui-Malki, B. Jannin, L. Dubrez-Daloz, N. Latruffe, et al. Resveratrol-induced Apoptosis Is Associated with Fas Redistribution in the Rafts and the Formation of a Death-inducing Signaling Complex in Colon Cancer Cells J. Biol. Chem., October 17, 2003; 278(42): 41482 - 41490. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Okino, X. He, S. Gatt, K. Sandhoff, M. Ito, and E. H. Schuchman The Reverse Activity of Human Acid Ceramidase J. Biol. Chem., August 8, 2003; 278(32): 29948 - 29953. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bieberich, S. MacKinnon, J. Silva, S. Noggle, and B. G. Condie Regulation of cell death in mitotic neural progenitor cells by asymmetric distribution of prostate apoptosis response 4 (PAR-4) and simultaneous elevation of endogenous ceramide J. Cell Biol., August 4, 2003; 162(3): 469 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Silins, M. Nordstrand, J. Hogberg, and U. Stenius Sphingolipids suppress preneoplastic rat hepatocytes in vitro and in vivo Carcinogenesis, June 1, 2003; 24(6): 1077 - 1083. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Y. Fan, D. N. McMurray, L. H. Ly, and R. S. Chapkin Dietary (n-3) Polyunsaturated Fatty Acids Remodel Mouse T-Cell Lipid Rafts J. Nutr., June 1, 2003; 133(6): 1913 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Barsacchi, C. Perrotta, S. Bulotta, S. Moncada, N. Borgese, and E. Clementi Activation of Endothelial Nitric-Oxide Synthase by Tumor Necrosis Factor-alpha : A Novel Pathway Involving Sequential Activation of Neutral Sphingomyelinase, Phosphatidylinositol-3' kinase, and Akt Mol. Pharmacol., April 1, 2003; 63(4): 886 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tani, H. Iida, and M. Ito O-Glycosylation of Mucin-like Domain Retains the Neutral Ceramidase on the Plasma Membranes as a Type II Integral Membrane Protein J. Biol. Chem., March 14, 2003; 278(12): 10523 - 10530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Garofalo, R. Misasi, V. Mattei, A. M. Giammarioli, W. Malorni, G. M. Pontieri, A. Pavan, and M. Sorice Association of the Death-inducing Signaling Complex with Microdomains after Triggering through CD95/Fas. EVIDENCE FOR CASPASE-8-GANGLIOSIDE INTERACTION IN T CELLS J. Biol. Chem., February 28, 2003; 278(10): 8309 - 8315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Switzer, D. N. McMurray, J. S. Morris, and R. S. Chapkin (n-3) Polyunsaturated Fatty Acids Promote Activation-Induced Cell Death in Murine T Lymphocytes J. Nutr., February 1, 2003; 133(2): 496 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Ducoroy, O. Micheau, S. Perruche, L. Dubrez-Daloz, D. de Fornel, P. Dutartre, P. Saas, and E. Solary LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level Blood, January 1, 2003; 101(1): 194 - 201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Jarad, B. Wang, S. Khan, J. DeVore, H. Miao, K. Wu, S. L. Nishimura, B. A. Wible, M. Konieczkowski, J. R. Sedor, et al. Fas Activation Induces Renal Tubular Epithelial Cell beta 8 Integrin Expression and Function in the Absence of Apoptosis J. Biol. Chem., November 27, 2002; 277(49): 47826 - 47833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Krippner-Heidenreich, F. Tubing, S. Bryde, S. Willi, G. Zimmermann, and P. Scheurich Control of Receptor-induced Signaling Complex Formation by the Kinetics of Ligand/Receptor Interaction J. Biol. Chem., November 8, 2002; 277(46): 44155 - 44163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Pru, I. R. Hendry, J. S. Davis, and B. R. Rueda Soluble Fas Ligand Activates the Sphingomyelin Pathway and Induces Apoptosis in Luteal Steroidogenic Cells Independently of Stress-Activated p38MAPK Endocrinology, November 1, 2002; 143(11): 4350 - 4357. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H. Li, M. S. Kluger, L. A. Madge, L. Zheng, A. L. M. Bothwell, and J. S. Pober Interferon-{gamma} Augments CD95(APO-1/Fas) and Pro-Caspase-8 Expression and Sensitizes Human Vascular Endothelial Cells to CD95-Mediated Apoptosis Am. J. Pathol., October 1, 2002; 161(4): 1485 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Grassme, J. Bock, J. Kun, and E. Gulbins Clustering of CD40 Ligand Is Required to Form a Functional Contact with CD40 J. Biol. Chem., August 9, 2002; 277(33): 30289 - 30299. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Ayllon, A. Fleischer, X. Cayla, A. Garcia, and A. Rebollo Segregation of Bad from Lipid Rafts Is Implicated in the Induction of Apoptosis J. Immunol., April 1, 2002; 168(7): 3387 - 3393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Algeciras-Schimnich, L. Shen, B. C. Barnhart, A. E. Murmann, J. K. Burkhardt, and M. E. Peter Molecular Ordering of the Initial Signaling Events of CD95 Mol. Cell. Biol., January 1, 2002; 22(1): 207 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Grassme, V. Jendrossek, J. Bock, A. Riehle, and E. Gulbins Ceramide-Rich Membrane Rafts Mediate CD40 Clustering J. Immunol., January 1, 2002; 168(1): 298 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cremesti, F. Paris, H. Grassme, N. Holler, J. Tschopp, Z. Fuks, E. Gulbins, and R. Kolesnick Ceramide Enables Fas to Cap and Kill J. Biol. Chem., June 22, 2001; 276(26): 23954 - 23961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Xu, R. Bittman, G. Duportail, D. Heissler, C. Vilcheze, and E. London Effect of the Structure of Natural Sterols and Sphingolipids on the Formation of Ordered Sphingolipid/Sterol Domains (Rafts). COMPARISON OF CHOLESTEROL TO PLANT, FUNGAL, AND DISEASE-ASSOCIATED STEROLS AND COMPARISON OF SPHINGOMYELIN, CEREBROSIDES, AND CERAMIDE J. Biol. Chem., August 31, 2001; 276(36): 33540 - 33546. [Abstract] [Full Text] [PDF]
|
|
