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Papers In Press, published online ahead of print January 11, 2002
J. Biol. Chem, 10.1074/jbc.M106955200
Submitted on July 23, 2001
Revised on January 11, 2002
Accepted on January 10, 2002
Klinikum Rechts der Isar, Exp Oncology and Therapy, Munich 81675
Corresponding Author: per.s.holm{at}lrz.tum.de
The adenovirus early proteins E1A and E1B-55KDa are key regulators of viral DNA replication and it was thought that targeting of p53 by E1B-55KDa is essential for this process. Here we have indentified a previously unrecognized function of E1B for adenovirus replication. We found that E1B-55KDa is involved in targeting the transcription factor YB-1 to the nuclei of adenovirus type 5 infected cells where it is associated with viral inclusion bodies believed to be sites of viral transcription and replication. We show that YB-1 facilitates E2 gene expression through the E2 late promoter thus controlling E2 gene activity at later stages of infection. The role of YB-1 for adenovirus replication was demonstrated with an E1-minus adenovirus vector containing a YB-1 transgene. In infected cells, AdYB-1 efficiently replicated and produced infectious progeny particles. Thus adenovirus E1B-55KDa protein and the host cell factor YB-1 act jointly to facilitate adenovirus replication.
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