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M108476200v1
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Papers In Press, published online ahead of print October 26, 2001
J. Biol. Chem, 10.1074/jbc.M108476200
Submitted on September 4, 2001
Revised on October 25, 2001
Accepted on October 26, 2001

ASB-2 inhibits growth and promotes commitment in Myeloid leukemia cells

Florence C. Guibal, Christel Moog-Lutz, Piotr Smolewski, Yolande Di Gioia, Zbigniew Darzynkiewicz, Pierre G. Lutz, and Yvon E. Cayre

Hopital Saint-Antoine, Unité INSERM 417, Paris 75012

Corresponding Author: cayre{at}st-antoine.inserm.fr

In acute promyelocytic leukemia (APL) cells harboring the PML-RARa chimeric protein, retinoic acid (RA)-induced differentiation is triggered through a PML-RARa signaling resulting in activation of critical target genes. Induced differentiation of APL cells is always preceded by withdrawal from the cell cycle and commitment events leading to terminal differentiation. Here we have identified the human Ankyrin repeat-containing protein with a suppressor of cytokines signaling (SOCS) Box-2 (ASB-2) cDNA, as a novel RA-induced gene in APL cells. PML-RARa strongly enhanced RA-induced ASB-2 mRNA expression. In myeloid leukemia cells, ASB-2 expression induced growth-inhibition and chromatin condensation recapitulating early events critical to RA-induced differentiation of APL cells.


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