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Papers In Press, published online ahead of print April 8, 2002
J. Biol. Chem, 10.1074/jbc.M200192200
Submitted on January 8, 2002
Revised on April 2, 2002
Accepted on April 5, 2002
Tumor Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Bunkyo-ku, Tokyo 113-8613
Corresponding Author: suhara{at}rinshoken.or.jp
Infections of bacteria and viruses induce host defense reactions known as innate responses including the activation of Interferon Regulatory Factor-3 (IRF-3), critical for the activation of type I interferon system. Upon immediate early signals triggered by the infection, IRF-3 is phosphorylated and a homodimer results. The homodimer complexes with the coactivator CREB binding protein (CBP)/p300 in the nucleus, thus holocomplex of IRF-3, competent in DNA binding is generated. We showed that CBP/p300 to be indispensable for the DNA binding activity of the holocomplex and to aid the binding through direct interaction with the DNA. We demonstrated that p300 binds with the IRF-3 homodimer via a Q-rich domain and that an intact histone acetyl transferase (HAT) domain is indispensable for the DNA binding of the holocomplex along with a CH3 domain, which connects the HAT and Q-rich domains. These results highlight a novel function of CBP/p300: direct involvement in sequence-specific DNA binding. Furthermore, the critical function of these domains in virus-induced gene activation was demonstrated in vivo by using p300 mutants.
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