| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print May 7, 2002
J. Biol. Chem, 10.1074/jbc.M201429200
Submitted on February 12, 2002
Revised on May 6, 2002
Accepted on May 7, 2002
and 
) regulate phosphoenolpyrvate carboxykinase (PEPCK) gene expression
Pharmacology, University of Tennessee, Memphis, TN 38163
Corresponding Author: epark{at}utmem.edu
Thyroid hormone and cAMP stimulate transcription of the gene for phosphoenolpyruvate carboxykinase (PEPCK). CCAAT enhancer binding proteins (C/EBP
and 
) are involved in multiple aspects of the nutritional, developmental and hormonal regulation of PEPCK gene expression. Previously, we have identified a thyroid hormone response element in the PEPCK promoter and demonstrated that C/EBP proteins bound to the P3(I) site are participants in the induction of PEPCK gene expression by thyroid hormone and cAMP. Here, we identify several peptide regions within the transactivation domain of C/EBP that enhance the ability of T3 to stimulate gene transcription. We also demonstrate that several conserved amino acids in the transactivation domain of C/EBP and C/EBP are required for the stimulation of basal gene expression and identify amino acids within C/EBP that participate in the cAMP induction of the PEPCK gene. Finally, we show that the CREB binding protein (CBP) enhanced the induction of PEPCK gene transcription by thyroid hormone and that CBP is associated with the PEPCK gene in vivo. Our results indicate that both C/EBP proteins and CBP participate in the regulation of PEPCK gene transcription by thyroid hormone.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Deng, C. Yellaturu, L. Cagen, H. G. Wilcox, E. A. Park, R. Raghow, and M. B. Elam Expression of the Rat Sterol Regulatory Element-binding Protein-1c Gene in Response to Insulin Is Mediated by Increased Transactivating Capacity of Specificity Protein 1 (Sp1) J. Biol. Chem., June 15, 2007; 282(24): 17517 - 17529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. McFie, G.-L. Wang, N. A. Timchenko, H. L. Wilson, X. Hu, and W. J. Roesler Identification of a Co-repressor That Inhibits the Transcriptional and Growth-Arrest Activities of CCAAT/Enhancer-binding Protein {alpha} J. Biol. Chem., June 30, 2006; 281(26): 18069 - 18080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. B. Scribner, D. P. Odom, and M. M. McGrane Vitamin A Status in Mice Affects the Histone Code of the Phosphoenolpyruvate Carboxykinase Gene in Liver J. Nutr., December 1, 2005; 135(12): 2774 - 2779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Ma, Y. Zhang, M. B. Elam, G. A. Cook, and E. A. Park Cloning of the Rat Pyruvate Dehydrogenase Kinase 4 Gene Promoter: ACTIVATION OF PYRUVATE DEHYDROGENASE KINASE 4 BY THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR {gamma} COACTIVATOR J. Biol. Chem., August 19, 2005; 280(33): 29525 - 29532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Schrem, J. Klempnauer, and J. Borlak Liver-Enriched Transcription Factors in Liver Function and Development. Part II: the C/EBPs and D Site-Binding Protein in Cell Cycle Control, Carcinogenesis, Circadian Gene Regulation, Liver Regeneration, Apoptosis, and Liver-Specific Gene Regulation Pharmacol. Rev., June 1, 2004; 56(2): 291 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-h. Shih, S.-L. Chen, C.-C. Yen, Y.-H. Huang, C.-d. Chen, Y.-S. Lee, and K.-h. Lin Thyroid Hormone Receptor-Dependent Transcriptional Regulation of Fibrinogen and Coagulation Proteins Endocrinology, June 1, 2004; 145(6): 2804 - 2814. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Scribner and M. M. McGrane RNA Polymerase II Association with the Phosphoenolpyruvate Carboxykinase (PEPCK) Promoter Is Reduced in Vitamin A-Deficient Mice J. Nutr., December 1, 2003; 133(12): 4112 - 4117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Kovacs, M. Steinmann, P. J. Magistretti, O. Halfon, and J.-R. Cardinaux CCAAT/Enhancer-binding Protein Family Members Recruit the Coactivator CREB-binding Protein and Trigger Its Phosphorylation J. Biol. Chem., September 19, 2003; 278(38): 36959 - 36965. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Jackson-Hayes, S. Song, E. N. Lavrentyev, M. S. Jansen, F. B. Hillgartner, L. Tian, P. A. Wood, G. A. Cook, and E. A. Park A Thyroid Hormone Response Unit Formed between the Promoter and First Intron of the Carnitine Palmitoyltransferase-Ialpha Gene Mediates the Liver-specific Induction by Thyroid Hormone J. Biol. Chem., February 28, 2003; 278(10): 7964 - 7972. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
