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Papers In Press, published online ahead of print March 13, 2002
Department of Biochemisty, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011
Corresponding Author: msh{at}iastate.edu
We have identified a new human hemoglobin that we call histoglobin, because it is expressed in a wide array of tissues. Histoglobin shares less than 30% identity with the other human hemoglobins, and the gene contains an intron in an unprecedented location. Spectroscopic and kinetic experiments with recombinant human histoglobin indicate that it is a hexacoordinate hemoglobin with significantly different ligand binding characteristics than the other human hexacoordinate hemoglobin, neuroglobin. In contrast to the very high oxygen affinities displayed by most hexacoordinate hemoglobins, the biophysical characteristics of histoglobin indicate that it could facilitate oxygen transport. The discovery of histoglobin demonstrates that humans, like plants, differentially express multiple hexacoordinate hemoglobins.
J. Biol. Chem, 10.1074/jbc.M201934200
Submitted on February 26, 2002
Revised on March 12, 2002
Accepted on March 13, 2002
A ubiquitously expressed human hexacoordinate hemoglobin
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