| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print January 14, 2003
The Hormel Institute, University of Minnesota, Austin, MN 55912
Corresponding Author: zgdong{at}hi.umn.edu
Arsenite is known to be an environmental human carcinogen. However, the mechanism of action of this compound in skin carcinogenesis is not completely clear. Here, we provide evidence that arsenite can induce phosphorylation of histone H3 at serine 10 in a time- and dose-dependent manner in JB6 Cl41 cells. Arsenite induces phosphorylation of Akt1 at serine 473 and increases Akt1 activity. A dominant-negative mutant of Akt1 inhibits the arsenite-induced phosphorylation of histone H3 at serine 10. Additionally, active Akt1 kinase strongly phosphorylates histone H3 at serine 10 in vitro. The arsenite-induced phosphorylation of histone H3 at serine 10 was almost completely blocked by a dominant-negative mutant of ERK2 and the MEK inhibitor PD98059. N- or C-terminal mutant MSK1 or the MSK1 inhibitor H89 had no effect on arsenite-induced phosphorylation of histone H3 at serine 10 in JB6 Cl41 cells. However, cells deficient in RSK2 (Rsk2-/-) totally blocks this phosphorylation in a dose- and time-dependent manner. Taken together, these results suggested that arsenite-induced phosphorylation at serine 10 is mediated by Akt1, ERK2 and RSK2 but not MSK1.
J. Biol. Chem, 10.1074/jbc.M208581200
Submitted on August 21, 2002
Revised on January 2, 2003
Accepted on January 14, 2003
Arsenite-induced phosphorylation of histone H3 at serine 10 is mediated by Akt1, ERK2, and RSK2 but not MSK1
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Q. Ke, Q. Li, T. P. Ellen, H. Sun, and M. Costa Nickel compounds induce phosphorylation of histone H3 at serine 10 by activating JNK-MAPK pathway Carcinogenesis, June 1, 2008; 29(6): 1276 - 1281. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. R. Lee, F. E. Murdoch, and M. K. Fritsch High Histone Acetylation and Decreased Polycomb Repressive Complex 2 Member Levels Regulate Gene Specific Transcriptional Changes During Early Embryonic Stem Cell Differentiation Induced by Retinoic Acid Stem Cells, September 1, 2007; 25(9): 2191 - 2199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Burkhart, S. B. Kennett, and T. K. Archer Osmotic Stress-dependent Repression Is Mediated by Histone H3 Phosphorylation and Chromatin Structure J. Biol. Chem., February 16, 2007; 282(7): 4400 - 4407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. R. Lee, K. W. McCool, F. E. Murdoch, and M. K. Fritsch Dynamic Changes in Histone H3 Phosphoacetylation during Early Embryonic Stem Cell Differentiation Are Directly Mediated by Mitogen- and Stress-activated Protein Kinase 1 via Activation of MAPK Pathways J. Biol. Chem., July 28, 2006; 281(30): 21162 - 21172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, S. Batra, S. Korrapati, V. Mishra, and K. D. Mehta Selective Repression of Low-Density Lipoprotein Receptor Expression by SP600125: Coupling of Histone H3-Ser10 Phosphorylation and Sp1 Occupancy Mol. Cell. Biol., February 15, 2006; 26(4): 1307 - 1317. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Schmeck, W. Beermann, V. van Laak, J. Zahlten, B. Opitz, M. Witzenrath, A. C. Hocke, T. Chakraborty, M. Kracht, S. Rosseau, et al. Intracellular Bacteria Differentially Regulated Endothelial Cytokine Release by MAPK-Dependent Histone Modification J. Immunol., September 1, 2005; 175(5): 2843 - 2850. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Bode and Z. Dong Inducible Covalent Posttranslational Modification of Histone H3 Sci. Signal., April 26, 2005; 2005(281): re4 - re4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. He, Y.-Y. Cho, W.-Y. Ma, H. S. Choi, A. M. Bode, and Z. Dong Regulation of Ultraviolet B-induced Phosphorylation of Histone H3 at Serine 10 by Fyn Kinase J. Biol. Chem., January 28, 2005; 280(4): 2446 - 2454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Huang, V. Mishra, S. Batra, I. Dillon, and K. D. Mehta Phorbol ester promotes histone H3-Ser10 phosphorylation at the LDL receptor promoter in a protein kinase C-dependent manner J. Lipid Res., August 1, 2004; 45(8): 1519 - 1527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Moggs and G. Orphanides The Role of Chromatin in Molecular Mechanisms of Toxicity Toxicol. Sci., August 1, 2004; 80(2): 218 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Wang and S. J. Lippard Cisplatin-induced Post-translational Modification of Histones H3 and H4 J. Biol. Chem., May 14, 2004; 279(20): 20622 - 20625. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
