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Papers In Press, published online ahead of print October 1, 2002
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6H 3Z6
Corresponding Author: mrao{at}vanhosp.bc.ca
The androgen receptor (AR) is a ligand-dependent transcription factor that has an essential role in the normal growth, development and maintenance of the prostate gland. The AR is part of a large family of steroid receptors that also includes the glucocorticoid, progesterone and mineralocorticoid receptors (GR, PR and MR respectively). Steroid receptor family members share significant homology at their DNA and ligand binding domains. However, these receptors exhibit a high degree of sequence variability at their NH2-terminal domain, which suggests the possibility of receptor-specific interactions with co-regulator proteins. Transcriptional co-regulators that interact with the AR may have a role in defining AR-activity and may be involved in directing AR-specific responses. Here we have identified RanBPM to be a novel AR-interacting protein by yeast two-hybrid assay and have confirmed this interaction by GST- and His-tag pull down assays. In addition, transient over-expression of RanBPM in prostate cancer cell lines resulted in enhanced AR activity in a ligand-dependent fashion. GR activity was also enhanced when RanBPM was over-expressed, while ER activity remained unchanged. These data demonstrate that RanBPM interacts with steroid receptors to selectively modify their activity.
J. Biol. Chem, 10.1074/jbc.M209741200
Submitted on September 23, 2002
Revised on October 1, 2002
Accepted on September 30, 2002
RanBPM: A nuclear protein that interacts with and regulates transcriptional activity of Androgen receptor and Glucocorticoid receptor
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